Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HMGB1 (high mobility group box 1) Homo sapiens
Symbol: HMGB1
Name: high mobility group box 1
Description: Exhibits several functions, including DNA binding activity; DNA polymerase binding activity; and lipopolysaccharide binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of cytokine production; and regulation of cell migration. Localizes to several cellular components, including the alphav-beta3 integrin-HMGB1 complex; cell surface; and condensed chromosome. Implicated in amyotrophic lateral sclerosis. Biomarker of Kawasaki disease; cerebral infarction; congestive heart failure; and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Amphoterin; DKFZp686A04236; high mobility group protein 1; high mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG-1; HMG1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein
Mus musculus (house mouse) : Hmgb1 (high mobility group box 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmgb1 (high mobility group box 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgb1 (high mobility group box 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGB1 (high mobility group box 1)
Canis lupus familiaris (dog) : HMGB1 (high mobility group box 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgb1 (high mobility group box 1)
Sus scrofa (pig) : HMGB1 (high mobility group box 1)
more info ...
Related Pseudogenes: HMGB1P1   HMGB1P10   HMGB1P14   HMGB1P15   HMGB1P16   HMGB1P17   HMGB1P18   HMGB1P19   HMGB1P20   HMGB1P21   HMGB1P22   HMGB1P23   HMGB1P24   HMGB1P25   HMGB1P26   HMGB1P27   HMGB1P28   HMGB1P29   HMGB1P3   HMGB1P30   HMGB1P31   HMGB1P32   HMGB1P33   HMGB1P38   HMGB1P4   HMGB1P40   HMGB1P41   HMGB1P42   HMGB1P47   HMGB1P48   HMGB1P5   HMGB1P50   HMGB1P51   HMGB1P6   HMGB1P7   HMGB1P8   HMGB1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381330,456,704 - 30,617,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371331,032,877 - 31,191,942 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361329,930,877 - 29,938,081 (-)NCBINCBI36hg18NCBI36
Celera1312,102,423 - 12,109,630 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef1311,850,667 - 11,857,904 (-)NCBIHuRef
CHM1_11330,999,610 - 31,159,427 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HMGB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605729
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.