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Gene: DRD3 (dopamine receptor D3) Homo sapiens
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Symbol: DRD3
Name: dopamine receptor D3
Description: Exhibits dopamine neurotransmitter receptor activity, coupled via Gi/Go and drug binding activity. Involved in several processes, including arachidonic acid secretion; behavioral response to cocaine; and dopamine receptor signaling pathway. Localizes to the integral component of plasma membrane. Implicated in essential tremor and schizophrenia. Biomarker of Alzheimer's disease and Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D(3) dopamine receptor; D3DR; dopamine D3 receptor; essential tremor 1; ETM1; FET1; MGC149204; MGC149205
Orthologs:
Mus musculus (house mouse) : Drd3 (dopamine receptor D3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Drd3 (dopamine receptor D3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd3 (dopamine receptor D3)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD3 (dopamine receptor D3)
Canis lupus familiaris (dog) : DRD3 (dopamine receptor D3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd3 (dopamine receptor D3)
Sus scrofa (pig) : DRD3 (dopamine receptor D3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373113,847,499 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBI
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,844 - 113,881,272 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DRD3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605735
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.