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Gene: ATRX (ATRX chromatin remodeler) Homo sapiens
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Symbol: ATRX
Name: ATRX chromatin remodeler
Description: Exhibits several functions, including DNA translocase activity; chromo shadow domain binding activity; and methylated histone binding activity. Involved in chromatin organization; positive regulation of telomeric RNA transcription from RNA pol II promoter; and regulation of chromosome organization. Localizes to nuclear body and nuclear subtelomeric heterochromatin. Implicated in alpha thalassemia-X-linked intellectual disability syndrome and malignant glioma. Biomarker of astrocytoma; glioblastoma multiforme; melanoma; and sarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha thalassemia/mental retardation syndrome X-linked; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; ATR2; ATRX, chromatin remodeler; DNA dependent ATPase and helicase; helicase 2, X-linked; JMS; Juberg-Marsidi syndrome; mental retardation, X-linked 52; MGC2094; MRX52; MRXHF1; RAD54; RAD54 homolog; RAD54L; SFM1; SHS; Sutherland-Haan X-linked mental retardation syndrome; transcriptional regulator ATRX; X-linked helicase II; X-linked nuclear protein; XH2; XNP; Zinc finger helicase; ZNF-HX
Orthologs:
Mus musculus (house mouse) : Atrx (ATRX, chromatin remodeler)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atrx (ATRX, chromatin remodeler)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atrx (ATRX chromatin remodeler)
Pan paniscus (bonobo/pygmy chimpanzee) : ATRX (ATRX chromatin remodeler)
Canis lupus familiaris (dog) : ATRX (ATRX chromatin remodeler)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atrx (ATRX chromatin remodeler)
Sus scrofa (pig) : ATRX (ATRX chromatin remodeler)
Chlorocebus sabaeus (African green monkey) : ATRX (ATRX chromatin remodeler)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX77,504,878 - 77,786,233 (-)EnsemblGRCh38hg38GRCh38
GRCh38X77,504,878 - 77,786,235 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X76,760,356 - 77,041,755 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X76,647,012 - 76,928,375 (-)NCBINCBI36hg18NCBI36
CeleraX77,001,253 - 77,282,613 (-)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX70,349,443 - 70,629,029 (-)NCBIHuRef
CHM1_1X76,653,073 - 76,934,456 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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