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Gene: UPRT (uracil phosphoribosyltransferase homolog) Homo sapiens
Symbol: UPRT
Name: uracil phosphoribosyltransferase homolog
Description: This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781E1243; FUR1; MGC23937; RP11-311P8.3; UMP pyrophosphorylase; UPP; UPRTase; uracil phosphoribosyltransferase (FUR1) homolog
Mus musculus (house mouse) : Uprt (uracil phosphoribosyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Uprt (uracil phosphoribosyltransferase homolog)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uprt (uracil phosphoribosyltransferase homolog)
Pan paniscus (bonobo/pygmy chimpanzee) : UPRT (uracil phosphoribosyltransferase homolog)
Canis lupus familiaris (dog) : UPRT (uracil phosphoribosyltransferase homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uprt (uracil phosphoribosyltransferase homolog)
Sus scrofa (pig) : UPRT (uracil phosphoribosyltransferase homolog)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X75,156,379 - 75,304,897 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X74,493,894 - 74,524,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X74,410,686 - 74,441,159 (+)NCBINCBI36hg18NCBI36
CeleraX74,777,320 - 74,808,158 (+)NCBI
Cytogenetic MapXq13.3NCBI
HuRefX68,128,874 - 68,159,480 (+)NCBIHuRef
CHM1_1X74,386,787 - 74,417,624 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UPRT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605870
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.