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Gene: UPRT (uracil phosphoribosyltransferase homolog) Homo sapiens
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Symbol: UPRT
Name: uracil phosphoribosyltransferase homolog
Description: This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781E1243; FUR1; MGC23937; RP11-311P8.3; UMP pyrophosphorylase; UPP; UPRTase; uracil phosphoribosyltransferase (FUR1) homolog
Orthologs:
Mus musculus (house mouse) : Uprt (uracil phosphoribosyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Uprt (uracil phosphoribosyltransferase homolog)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uprt (uracil phosphoribosyltransferase homolog)
Pan paniscus (bonobo/pygmy chimpanzee) : UPRT (uracil phosphoribosyltransferase homolog)
Canis lupus familiaris (dog) : UPRT (uracil phosphoribosyltransferase homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uprt (uracil phosphoribosyltransferase homolog)
Sus scrofa (pig) : UPRT (uracil phosphoribosyltransferase homolog)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X75,156,379 - 75,304,897 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X74,493,894 - 74,524,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X74,410,686 - 74,441,159 (+)NCBINCBI36hg18NCBI36
CeleraX74,777,320 - 74,808,158 (+)NCBI
Cytogenetic MapXq13.3NCBI
HuRefX68,128,874 - 68,159,480 (+)NCBIHuRef
CHM1_1X74,386,787 - 74,417,624 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on UPRT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605870
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.