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Gene: VSIR (V-set immunoregulatory receptor) Homo sapiens
Symbol: VSIR
Name: V-set immunoregulatory receptor
Description: Exhibits endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Localizes to the plasma membrane; INTERACTS WITH 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B7-H5; B7H5; C10orf54; chromosome 10 open reading frame 54; DD1alpha; Death Domain1alpha; Dies1; GI24; PD-1H; PDCD1 homolog; platelet receptor Gi24; PP2135; sisp-1; SISP1; stress induced secreted protein 1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; V-set domain-containing immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation; VISTA
Mus musculus (house mouse) : Vsir (V-set immunoregulatory receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vsir (V-set immunoregulatory receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vsir (V-set immunoregulatory receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : VSIR (V-set immunoregulatory receptor)
Canis lupus familiaris (dog) : VSIR (V-set immunoregulatory receptor)
Sus scrofa (pig) : VSIR (V-set immunoregulatory receptor)
Chlorocebus sabaeus (African green monkey) : VSIR (V-set immunoregulatory receptor)
Heterocephalus glaber (naked mole-rat) : Vsir (V-set immunoregulatory receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1071,747,556 - 71,773,520 (-)EnsemblGRCh38hg38GRCh38
GRCh381071,747,556 - 71,773,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371073,507,313 - 73,533,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,177,319 - 73,203,343 (-)NCBINCBI36hg18NCBI36
Celera1066,789,752 - 66,815,911 (-)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1067,501,145 - 67,527,120 (-)NCBIHuRef
CHM1_11073,789,445 - 73,815,328 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on VSIR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605963
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.