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Gene: DNMT3B (DNA methyltransferase 3 beta) Homo sapiens
Symbol: DNMT3B
Name: DNA methyltransferase 3 beta
Description: Exhibits DNA (cytosine-5-)-methyltransferase activity and transcription corepressor activity. Involved in regulation of gene expression and regulation of histone methylation. Localizes to nucleoplasm. Implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Biomarker of several diseases, including autoimmune thrombocytopenic purpura; endometriosis (multiple); gastrointestinal system cancer (multiple); myeloid leukemia (multiple); and pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA cytosine-5--methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; ICF; ICF1; M.HsaIIIB
Mus musculus (house mouse) : Dnmt3b (DNA methyltransferase 3B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnmt3b (DNA methyltransferase 3 beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt3b (DNA methyltransferase 3 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT3B (DNA methyltransferase 3 beta)
Canis lupus familiaris (dog) : DNMT3B (DNA methyltransferase 3 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt3b (DNA methyltransferase 3 beta)
Sus scrofa (pig) : DNMT3B (DNA methyltransferase 3 beta)
Chlorocebus sabaeus (African green monkey) : DNMT3B (DNA methyltransferase 3 beta)
Heterocephalus glaber (naked mole-rat) : Dnmt3b (DNA methyltransferase 3 beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2032,762,385 - 32,809,356 (+)EnsemblGRCh38hg38GRCh38
GRCh382032,762,385 - 32,809,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372031,350,191 - 31,397,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,813,852 - 30,860,823 (+)NCBINCBI36hg18NCBI36
Celera2028,104,119 - 28,151,087 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2028,137,312 - 28,184,284 (+)NCBIHuRef
CHM1_12031,253,633 - 31,300,607 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNMT3B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606037
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.