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Gene: H2BW1 (H2B.W histone 1) Homo sapiens
Symbol: H2BW1
Name: H2B.W histone 1
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H2B histone family member W testis-specific; H2B histone family member W, testis specific; H2B histone family, member W, testis-specific; H2BFWT; histone H2B type W-T; MGC148130; MGC148131
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100969533 (histone H2B type W-T)
Canis lupus familiaris (dog) : H2BFWT (H2B histone family, member W, testis-specific)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X104,011,147 - 104,013,687 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X103,265,719 - 103,268,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X103,152,376 - 103,154,912 (-)NCBINCBI36hg18NCBI36
CeleraX103,754,357 - 103,756,894 (+)NCBI
Cytogenetic MapXq22.2NCBI
HuRefX92,921,452 - 92,921,770 (-)NCBIHuRef
CHM1_1X103,172,780 - 103,175,320 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on H2BW1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606133
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.