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Gene: MAVS (mitochondrial antiviral signaling protein) Homo sapiens
Symbol: MAVS
Name: mitochondrial antiviral signaling protein
CRRD ID: 1606258
Description: Exhibits CARD domain binding activity; protein kinase binding activity; and signaling adaptor activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and regulation of defense response. Localizes to mitochondrial outer membrane and peroxisomal membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; CARDIF; DKFZp547C224; DKFZp666M015; FLJ27482; FLJ31698; FLJ35386; FLJ38051; FLJ41962; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; IPS1; KIAA1271; MGC3260; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter variant 1b; virus-induced signaling adaptor; virus-induced signaling adaptor variant 1a; virus-induced-signaling adapter; VISA
Mus musculus (house mouse) : Mavs (mitochondrial antiviral signaling protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mavs (mitochondrial antiviral signaling protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mavs (mitochondrial antiviral signaling protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MAVS (mitochondrial antiviral signaling protein)
Canis lupus familiaris (dog) : MAVS (mitochondrial antiviral signaling protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mavs (mitochondrial antiviral signaling protein)
Sus scrofa (pig) : MAVS (mitochondrial antiviral signaling protein)
Chlorocebus sabaeus (African green monkey) : MAVS (mitochondrial antiviral signaling protein)
Heterocephalus glaber (naked mole-rat) : Mavs (mitochondrial antiviral signaling protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl203,846,799 - 3,876,123 (+)EnsemblGRCh38hg38GRCh38
GRCh38203,846,834 - 3,876,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,827,446 - 3,856,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,775,484 - 3,795,973 (+)NCBINCBI36hg18NCBI36
Celera203,889,325 - 3,918,630 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef203,776,247 - 3,805,626 (+)NCBIHuRef
CHM1_1203,827,384 - 3,856,773 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAVS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606258
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.