Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DFFA (DNA fragmentation factor subunit alpha) Homo sapiens
Symbol: DFFA
Name: DNA fragmentation factor subunit alpha
Description: Exhibits deoxyribonuclease inhibitor activity; protein domain specific binding activity; and protein folding chaperone. Involved in chaperone-mediated protein folding; negative regulation of apoptotic DNA fragmentation; and negative regulation of deoxyribonuclease activity. Localizes to the cytosol; nuclear chromatin; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DFF-45; DFF1; DFF45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor, 45kDa, alpha polypeptide; ICAD; inhibitor of CAD
Mus musculus (house mouse) : Dffa (DNA fragmentation factor, alpha subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dffa (DNA fragmentation factor subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dffa (DNA fragmentation factor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : DFFA (DNA fragmentation factor subunit alpha)
Canis lupus familiaris (dog) : DFFA (DNA fragmentation factor subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dffa (DNA fragmentation factor subunit alpha)
Sus scrofa (pig) : DFFA (DNA fragmentation factor subunit alpha)
Chlorocebus sabaeus (African green monkey) : DFFA (DNA fragmentation factor subunit alpha)
Heterocephalus glaber (naked mole-rat) : Dffa (DNA fragmentation factor subunit alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl110,456,522 - 10,472,529 (-)Ensembl
GRCh38110,456,522 - 10,472,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37110,520,588 - 10,532,613 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,443,175 - 10,455,200 (-)NCBINCBI36hg18NCBI36
Celera19,631,993 - 9,644,017 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef19,674,182 - 9,686,174 (-)NCBIHuRef
CHM1_1110,508,330 - 10,520,370 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DFFA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606338
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.