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Gene: FASLG (Fas ligand) Homo sapiens
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Symbol: FASLG
Name: Fas ligand
Description: Predicted to have signaling receptor binding activity. Involved in several processes, including necroptotic signaling pathway; positive regulation of apoptotic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Localizes to the extracellular exosome; nucleus; and plasma membrane. Implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; multiple sclerosis; pancreatic cancer (multiple); and pre-eclampsia (multiple). Biomarker of several diseases, including bone marrow cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; clonorchiasis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS1B; apoptosis (APO-1) antigen ligand 1; apoptosis antigen ligand; APT1LG1; APTL; CD178; CD95 ligand; CD95-L; CD95L; fas antigen ligand; Fas ligand (TNF superfamily, member 6); FASL; mutant tumor necrosis factor family member 6; TNFSF6; TNLG1A; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand 1A; tumor necrosis factor ligand superfamily member 6
Orthologs:
Mus musculus (house mouse) : Fasl (Fas ligand (TNF superfamily, member 6))  MGI  Alliance
Rattus norvegicus (Norway rat) : Faslg (Fas ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Faslg (Fas ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : FASLG (Fas ligand)
Canis lupus familiaris (dog) : FASLG (Fas ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Faslg (Fas ligand)
Sus scrofa (pig) : FASLG (Fas ligand (TNF superfamily, member 6))
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1172,659,103 - 172,666,876 (+)Ensembl
GRCh381172,659,008 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,628,185 - 172,636,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBI
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,459 - 174,058,323 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FASLG
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606342
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.