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Gene: NOTUM (notum, palmitoleoyl-protein carboxylesterase) Homo sapiens
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Symbol: NOTUM
Name: notum, palmitoleoyl-protein carboxylesterase
Description: Exhibits palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Predicted to localize to the endoplasmic reticulum lumen and extracellular region; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: [Wnt protein] O-palmitoleoyl-L-serine hydrolase; hNOTUM; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog
Orthologs:
Mus musculus (house mouse) : Notum (notum palmitoleoyl-protein carboxylesterase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Notum (NOTUM, palmitoleoyl-protein carboxylesterase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notum (notum, palmitoleoyl-protein carboxylesterase)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTUM (notum, palmitoleoyl-protein carboxylesterase)
Canis lupus familiaris (dog) : NOTUM (notum, palmitoleoyl-protein carboxylesterase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notum (notum, palmitoleoyl-protein carboxylesterase)
Sus scrofa (pig) : NOTUM (notum, palmitoleoyl-protein carboxylesterase)
Chlorocebus sabaeus (green monkey) : NOTUM (notum, palmitoleoyl-protein carboxylesterase)
Heterocephalus glaber (naked mole-rat) : Notum (notum, palmitoleoyl-protein carboxylesterase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1781,952,507 - 81,961,840 (-)Ensembl
GRCh381781,952,507 - 81,961,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371779,910,383 - 79,919,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,503,678 - 77,512,353 (-)NCBINCBI36hg18NCBI36
Celera1776,514,308 - 76,540,092 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1775,311,107 - 75,319,589 (-)NCBIHuRef
CHM1_11779,996,557 - 80,005,040 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NOTUM
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606450
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.