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Gene: NKAP (NFKB activating protein) Homo sapiens
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Symbol: NKAP
Name: NFKB activating protein
Description: This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ22626; NF-kappa-B-activating protein; NF-kappaB activating protein
Orthologs:
Mus musculus (house mouse) : Nkap (NFKB activating protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkap (NFKB activating protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkap (NFKB activating protein)
Pan paniscus (bonobo/pygmy chimpanzee) : NKAP (NFKB activating protein)
Canis lupus familiaris (dog) : NKAP (NFKB activating protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkap (NFKB activating protein)
Sus scrofa (pig) : NKAP (NFKB activating protein)
more info ...
Related Pseudogenes: NKAPP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,925,050 - 119,943,772 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X119,059,013 - 119,077,735 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,943,051 - 118,961,763 (-)NCBINCBI36hg18NCBI36
CeleraX119,513,642 - 119,532,364 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,555,462 - 108,574,439 (-)NCBIHuRef
CHM1_1X118,970,042 - 118,988,764 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on NKAP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606506
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.