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Gene: NKAP (NFKB activating protein) Homo sapiens
Symbol: NKAP
Name: NFKB activating protein
Description: This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ22626; NF-kappa-B-activating protein; NF-kappaB activating protein
Mus musculus (house mouse) : Nkap (NFKB activating protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkap (NFKB activating protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkap (NFKB activating protein)
Pan paniscus (bonobo/pygmy chimpanzee) : NKAP (NFKB activating protein)
Canis lupus familiaris (dog) : NKAP (NFKB activating protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkap (NFKB activating protein)
Sus scrofa (pig) : NKAP (NFKB activating protein)
more info ...
Related Pseudogenes: NKAPP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X119,925,050 - 119,943,772 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X119,059,013 - 119,077,735 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,943,051 - 118,961,763 (-)NCBINCBI36hg18NCBI36
CeleraX119,513,642 - 119,532,364 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,555,462 - 108,574,439 (-)NCBIHuRef
CHM1_1X118,970,042 - 118,988,764 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKAP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606506
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.