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Gene: ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase) Homo sapiens
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Symbol: ERCC6L
Name: ERCC excision repair 6 like, spindle assembly checkpoint helicase
Description: This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; excision repair cross-complementation group 6 like; excision repair cross-complementation group 6-like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; excision repair protein ERCC6-like; FLJ20105; MGC131695; PICH; Plk1-interacting checkpoint helicase; RAD26L; SNF2/RAD54 family protein; tumor antigen BJ-HCC-15
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X72,204,655 - 72,239,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X71,424,507 - 71,458,877 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X71,341,232 - 71,375,583 (-)NCBINCBI36hg18NCBI36
CeleraX71,767,719 - 71,802,070 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX65,178,551 - 65,213,938 (-)NCBIHuRef
CHM1_1X71,317,573 - 71,351,927 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ERCC6L
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606557
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.