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Gene: PPEF1 (protein phosphatase with EF-hand domain 1) Homo sapiens
Symbol: PPEF1
Name: protein phosphatase with EF-hand domain 1
Description: This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PP7; PPEF; PPP7C; PPP7CA; protein phosphatase 7, catalytic subunit, alpha isozyme; protein phosphatase with EF calcium-binding domain; protein phosphatase, serine/threonine type, with EF-hands; serine/threonine protein phosphatase 7; serine/threonine-protein phosphatase 7; serine/threonine-protein phosphatase with EF-hands 1
Mus musculus (house mouse) : Ppef1 (protein phosphatase with EF hand calcium-binding domain 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppef1 (protein phosphatase with EF-hand domain 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppef1 (protein phosphatase with EF-hand domain 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PPEF1 (protein phosphatase with EF-hand domain 1)
Canis lupus familiaris (dog) : PPEF1 (protein phosphatase with EF-hand domain 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppef1 (protein phosphatase with EF-hand domain 1)
Sus scrofa (pig) : PPEF1 (protein phosphatase with EF-hand domain 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X18,675,909 - 18,827,921 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X18,704,257 - 18,846,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X18,618,966 - 18,755,956 (+)NCBINCBI36hg18NCBI36
CeleraX22,829,137 - 22,966,124 (+)NCBI
Cytogenetic MapXp22.13NCBI
HuRefX16,462,688 - 16,598,790 (+)NCBIHuRef
CHM1_1X18,740,148 - 18,877,076 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPEF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606579
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.