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Gene: GRK4 (G protein-coupled receptor kinase 4) Homo sapiens
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Symbol: GRK4
Name: G protein-coupled receptor kinase 4
CRRD ID: 1606583
Description: Predicted to have ATP binding activity; G protein-coupled receptor kinase activity; and rhodopsin kinase activity. Involved in receptor internalization. Predicted to localize to photoreceptor disc membrane. Implicated in essential hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: G protein-coupled receptor kinase 2-like; g protein-coupled receptor kinase GRK4; G-protein coupled receptor kinase 4; GPRK2L; GPRK4; GRK4a; IT11; ITI1
Orthologs:
Mus musculus (house mouse) : Grk4 (G protein-coupled receptor kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grk4 (G protein-coupled receptor kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk4 (G protein-coupled receptor kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK4 (G protein-coupled receptor kinase 4)
Canis lupus familiaris (dog) : GRK4 (G protein-coupled receptor kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk4 (G protein-coupled receptor kinase 4)
Sus scrofa (pig) : GRK4 (G protein-coupled receptor kinase 4)
Chlorocebus sabaeus (African green monkey) : GRK4 (G protein-coupled receptor kinase 4)
Heterocephalus glaber (naked mole-rat) : Grk4 (G protein-coupled receptor kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl42,963,571 - 3,040,760 (+)EnsemblGRCh38hg38GRCh38
GRCh3842,963,504 - 3,040,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3742,965,232 - 3,042,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,935,141 - 3,012,272 (+)NCBINCBI36hg18NCBI36
Celera42,876,244 - 2,953,687 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef42,903,673 - 2,980,923 (+)NCBIHuRef
CHM1_142,963,374 - 3,040,591 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GRK4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606583
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.