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Gene: CYP19A1 (cytochrome P450 family 19 subfamily A member 1) Homo sapiens
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Description: Exhibits aromatase activity and heme binding activity. Involved in androgen catabolic process and positive regulation of estradiol secretion. Localizes to the endoplasmic reticulum. Implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; female reproductive organ cancer (multiple); polycystic ovary syndrome; and prostate disease (multiple). Biomarker of Alzheimer's disease and endometriosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARO; ARO1; aromatase; CPV1; CYAR; CYP19; CYPXIX; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily XIX (aromatization of androgens); estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM
Mus musculus (house mouse) : Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102023780 (aromatase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100984744 (aromatase)
Canis lupus familiaris (dog) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101954950 (aromatase)
Sus scrofa (pig) : CYP19A2 (cytochrome P450 19A2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381551,208,057 - 51,338,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371551,500,254 - 51,630,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361549,288,961 - 49,418,086 (-)NCBINCBI36hg18NCBI36
Celera1528,393,650 - 28,524,194 (-)NCBI
Cytogenetic Map15q21.2NCBI
HuRef1528,330,314 - 28,460,872 (-)NCBIHuRef
CHM1_11551,618,344 - 51,748,904 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP19A1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606587
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.