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Gene: AK4 (adenylate kinase 4) Homo sapiens
Symbol: AK4
Name: adenylate kinase 4
Description: Exhibits adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Involved in several processes, including cellular response to hypoxia; nucleoside phosphate metabolic process; and regulation of phosphate metabolic process. Localizes to the mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenylate kinase 3-like 1; adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4; adenylate kinase isoenzyme 4, mitochondrial; AK 4; AK3; AK3L1; AK3L2; ATP-AMP transphosphorylase; GTP:AMP phosphotransferase; GTP:AMP phosphotransferase AK4; GTP:AMP phosphotransferase AK4, mitochondrial; MGC166959; mitochondrial adenylate kinase-3; nucleoside-triphosphate-adenylate kinase
Mus musculus (house mouse) : Ak4 (adenylate kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ak4 (adenylate kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ak4 (adenylate kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AK4 (adenylate kinase 4)
Canis lupus familiaris (dog) : AK4 (adenylate kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ak4 (adenylate kinase 4)
Sus scrofa (pig) : AK4 (adenylate kinase 4)
more info ...
Related Pseudogenes: AK4P1   AK4P2   AK4P3   AK4P4   AK4P5   AK4P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: On Build 36.2, AK3L1 and AK3L2 (GeneID 387851) were annotated at the same location. AK3L2 is defined as a locus on Chr12, which was annotated on Build 36.2 as GeneID 645619 on the reference assembly and 731007 on the Celera assembly. To remove the extra record, GeneID 387851 was merged into GeneID 205, and GeneID 645619 was renamed AK3L2. [13 Feb 2013]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38165,147,342 - 65,232,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37165,613,232 - 65,697,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,385,820 - 65,465,765 (+)NCBINCBI36hg18NCBI36
Celera163,903,944 - 63,988,555 (+)NCBI
Cytogenetic Map1p31.3NCBI
HuRef163,722,163 - 63,806,551 (+)NCBIHuRef
CHM1_1165,729,523 - 65,814,075 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AK4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606591
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.