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Gene: PDE12 (phosphodiesterase 12) Homo sapiens
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Symbol: PDE12
Name: phosphodiesterase 12
Description: Exhibits 3'-5'-exoribonuclease activity. Involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Localizes to the mitochondrial matrix; INTERACTS WITH 2-methylcholine; antirheumatic drug; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2',5'-phosphodiesterase 12; 2'-PDE; 2'-phosphodiesterase; 2-PDE; mitochondrial deadenylase
Orthologs:
Mus musculus (house mouse) : Pde12 (phosphodiesterase 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pde12 (phosphodiesterase 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde12 (phosphodiesterase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE12 (phosphodiesterase 12)
Canis lupus familiaris (dog) : PDE12 (phosphodiesterase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde12 (phosphodiesterase 12)
Sus scrofa (pig) : PDE12 (phosphodiesterase 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl357,556,274 - 57,566,848 (+)Ensembl
GRCh38357,556,274 - 57,656,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37357,541,882 - 57,640,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,517,044 - 57,522,720 (+)NCBINCBI36hg18NCBI36
Celera357,555,770 - 57,561,606 (+)NCBI
Cytogenetic Map3p14.3NCBI
HuRef357,639,405 - 57,645,202 (+)NCBIHuRef
CHM1_1357,492,074 - 57,592,295 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PDE12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1606683
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.