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Gene: P4HTM (prolyl 4-hydroxylase, transmembrane) Homo sapiens
Symbol: P4HTM
Name: prolyl 4-hydroxylase, transmembrane
CRRD ID: 1607023
Description: Exhibits 2-oxoglutarate-dependent dioxygenase activity. Predicted to contribute to procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to localize to endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EGLN4; HIDEA; HIF-PH4; HIF-prolyl hydroxylase 4; HIFPH4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H with transmembrane domain; P4H-TM; PH-4; PH4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; transmembrane prolyl 4-hydroxylase
Mus musculus (house mouse) : P4htm (prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum))  MGI  Alliance
Rattus norvegicus (Norway rat) : P4htm (prolyl 4-hydroxylase, transmembrane)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P4htm (prolyl 4-hydroxylase, transmembrane)
Pan paniscus (bonobo/pygmy chimpanzee) : P4HTM (prolyl 4-hydroxylase, transmembrane)
Canis lupus familiaris (dog) : P4HTM (prolyl 4-hydroxylase, transmembrane)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P4htm (prolyl 4-hydroxylase, transmembrane)
Sus scrofa (pig) : P4HTM (prolyl 4-hydroxylase, transmembrane)
Chlorocebus sabaeus (African green monkey) : P4HTM (prolyl 4-hydroxylase, transmembrane)
Heterocephalus glaber (naked mole-rat) : P4htm (prolyl 4-hydroxylase, transmembrane)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl348,989,889 - 49,007,153 (+)EnsemblGRCh38hg38GRCh38
GRCh38348,989,908 - 49,007,153 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,027,304 - 49,044,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,002,345 - 49,019,586 (+)NCBINCBI36hg18NCBI36
Celera348,981,987 - 48,999,268 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,085,262 - 49,102,385 (+)NCBIHuRef
CHM1_1348,979,918 - 48,997,136 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on P4HTM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1607023
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.