Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PIGA (phosphatidylinositol glycan anchor biosynthesis class A) Homo sapiens
Analyze
Symbol: PIGA
Name: phosphatidylinositol glycan anchor biosynthesis class A
Description: This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: class A GlcNAc-inositol phospholipid assembly protein; GLCNAC-PI synthesis protein; GPI anchor biosynthesis; GPI3; MCAHS2; phosphatidylinositol glycan anchor biosynthesis, class A; phosphatidylinositol N-acetylglucosaminyltransferase subunit A; phosphatidylinositol-glycan biosynthesis, class A protein; PIG-A; PNH1
Orthologs:
Related Pseudogenes: PIGAP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,319,451 - 15,335,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,337,573 - 15,353,676 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,247,499 - 15,263,581 (-)NCBINCBI36hg18NCBI36
CeleraX19,453,077 - 19,469,182 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,096,081 - 13,112,522 (-)NCBIHuRef
CHM1_1X15,368,527 - 15,384,630 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PIGA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1607087
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.