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Gene: H2-Q4 (histocompatibility 2, Q region locus 4) Mus musculus
Symbol: H2-Q4
Name: histocompatibility 2, Q region locus 4
CRRD ID: 1610420
Description: Predicted to have several functions, including TAP complex binding activity; beta-2-microglobulin binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to several cellular components, including Golgi medial cisterna; MHC class I protein complex; and endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in asthma and hepatitis C. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G); INTERACTS WITH 1,2-dimethylhydrazine; cadmium atom; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2Q4; H2-D1; H2-Gs1; H2-Gs10; MGC6571; MHC class I like protein GS10; MHC class II antigen D; Qa; Qa-; Qa-4; Qa4; Qat-; Qat-4; Qb-1; Qb1
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,598,593 - 35,603,650 (+)NCBI
GRCm381735,379,617 - 35,384,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,379,617 - 35,385,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,516,562 - 35,521,619NCBIGRCm37mm9NCBIm37
MGSCv361735,516,564 - 35,521,594 (+)NCBImm8
Cytogenetic Map17B1NCBI
cM Map1718.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on H2-Q4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1610420
Created: 2007-04-29
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.