Usp49 (ubiquitin specific peptidase 49) - Chinchilla Research Resource Database
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Gene: Usp49 (ubiquitin specific peptidase 49) Mus musculus
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Symbol: Usp49
Name: ubiquitin specific peptidase 49
CRRD ID: 1614183
Description: Predicted to have cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to localize to cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C330046L10Rik; deubiquitinating enzyme 49; Gm545; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific protease 49; ubiquitin thioesterase 49; ubiquitin thiolesterase 49; ubiquitin-specific-processing protease 49
Orthologs:
Homo sapiens (human) : USP49 (ubiquitin specific peptidase 49)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Usp49 (ubiquitin specific peptidase 49)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp49 (ubiquitin specific peptidase 49)
Pan paniscus (bonobo/pygmy chimpanzee) : USP49 (ubiquitin specific peptidase 49)
Canis lupus familiaris (dog) : USP49 (ubiquitin specific peptidase 49)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp49 (ubiquitin specific peptidase 49)
Sus scrofa (pig) : USP49 (ubiquitin specific peptidase 49)
Chlorocebus sabaeus (African green monkey) : USP49 (ubiquitin specific peptidase 49)
Heterocephalus glaber (naked mole-rat) : Usp49 (ubiquitin specific peptidase 49)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,941,615 - 47,997,664 (+)NCBI
GRCm381747,630,690 - 47,686,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,630,690 - 47,686,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,767,639 - 47,821,016 (+)NCBIGRCm37mm9NCBIm37
MGSCv361747,093,881 - 47,147,258 (+)NCBImm8
Celera1751,067,647 - 51,120,972 (+)NCBICelera
Cytogenetic Map17CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nucleus  (IEA)

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:30943264   PMID:32325033  


Genomics

Comparative Map Data
Usp49
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,941,615 - 47,997,664 (+)NCBI
GRCm381747,630,690 - 47,686,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,630,690 - 47,686,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,767,639 - 47,821,016 (+)NCBIGRCm37mm9NCBIm37
MGSCv361747,093,881 - 47,147,258 (+)NCBImm8
Celera1751,067,647 - 51,120,972 (+)NCBICelera
Cytogenetic Map17CNCBI
USP49
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl641,789,896 - 41,895,361 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,789,896 - 41,895,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,757,634 - 41,863,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,873,361 - 41,971,077 (-)NCBINCBI36hg18NCBI36
Celera643,318,714 - 43,416,439 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef641,484,106 - 41,581,878 (-)NCBIHuRef
CHM1_1641,760,993 - 41,866,405 (-)NCBICHM1_1
Usp49
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0915,314,875 - 15,375,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,317,413 - 15,375,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,239,085 - 14,299,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,774,333 - 8,832,285 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.198,778,351 - 8,786,793 (-)NCBI
Celera911,060,638 - 11,117,551 (-)NCBICelera
Cytogenetic Map9q12NCBI
Usp49
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,191,236 - 8,198,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,187,118 - 8,237,910 (-)NCBIChiLan1.0ChiLan1.0
USP49
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1642,678,680 - 42,781,748 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,683,149 - 42,695,707 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0641,375,083 - 41,479,143 (-)NCBIMhudiblu_PPA_v0panPan3
USP49
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1210,479,733 - 10,577,918 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11210,474,873 - 10,556,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Usp49
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647617,946,875 - 18,002,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,981,383 - 37,030,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,978,291 - 37,054,027 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,393,547 - 42,458,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP49
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1730,356,698 - 30,366,940 (+)Ensembl
ChlSab1.11730,265,322 - 30,373,547 (+)NCBI
Usp49
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,226,723 - 17,281,206 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4274029451432094Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174340000052800000Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174340000067500000Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174470566549059374Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse
35673315Ari1_mantibody response to influenza 1, day 7, IgG2a+IgG2c (mouse)174700000054400000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2828
Count of miRNA genes:898
Interacting mature miRNAs:1262
Transcripts:ENSMUST00000024779, ENSMUST00000131550, ENSMUST00000145314, ENSMUST00000152724
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024779   ⟹   ENSMUSP00000024779
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1747,630,690 - 47,686,738 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131550   ⟹   ENSMUSP00000118100
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1747,673,301 - 47,680,728 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145314   ⟹   ENSMUSP00000118675
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1747,649,621 - 47,672,184 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152724   ⟹   ENSMUSP00000120034
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1747,672,720 - 47,681,056 (+)Ensembl
RefSeq Acc Id: NM_198421   ⟹   NP_940813
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391747,941,615 - 47,997,664 (+)NCBI
GRCm381747,630,690 - 47,686,739 (+)NCBI
MGSCv371747,767,639 - 47,821,016 (+)RGD
Celera1751,067,647 - 51,120,972 (+)RGD
cM Map17 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_940813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60712 (Get FASTA)   NCBI Sequence Viewer  
  BAC38663 (Get FASTA)   NCBI Sequence Viewer  
  EDL23578 (Get FASTA)   NCBI Sequence Viewer  
  Q6P9L4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_940813   ⟸   NM_198421
- UniProtKB: Q6P9L4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000118675   ⟸   ENSMUST00000145314
RefSeq Acc Id: ENSMUSP00000120034   ⟸   ENSMUST00000152724
RefSeq Acc Id: ENSMUSP00000118100   ⟸   ENSMUST00000131550
RefSeq Acc Id: ENSMUSP00000024779   ⟸   ENSMUST00000024779
Protein Domains
USP

Promoters
RGD ID:13676302
Promoter ID:EPDNEW_M22300
Type:single initiation site
Name:Usp49_2
Description:Mus musculus ubiquitin specific peptidase 49 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22301  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381747,667,211 - 47,667,271EPDNEW
RGD ID:13676304
Promoter ID:EPDNEW_M22301
Type:single initiation site
Name:Usp49_1
Description:Mus musculus ubiquitin specific peptidase 49 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22300  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381747,672,036 - 47,672,096EPDNEW
RGD ID:6828866
Promoter ID:MM_KWN:23711
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour
Transcripts:OTTMUST00000044313
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361747,766,824 - 47,767,324 (+)MPROMDB
RGD ID:6828870
Promoter ID:MM_KWN:23713
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000083229,   UC008CVW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361747,809,424 - 47,809,924 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685391 AgrOrtholog
Ensembl Genes ENSMUSG00000090115 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024779 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000118100 UniProtKB/TrEMBL
  ENSMUSP00000118675 UniProtKB/TrEMBL
  ENSMUSP00000120034 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024779 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131550 UniProtKB/TrEMBL
  ENSMUST00000145314 UniProtKB/TrEMBL
  ENSMUST00000152724 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_UBP UniProtKB/Swiss-Prot
KEGG Report mmu:224836 UniProtKB/Swiss-Prot
MGD MGI:2685391 ENTREZGENE
NCBI Gene 224836 ENTREZGENE
Pfam UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-UBP UniProtKB/Swiss-Prot
PhenoGen Usp49 PhenoGen
PROSITE USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_UBP UniProtKB/Swiss-Prot
SMART ZnF_UBP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.59393 ENTREZGENE
UniProt D3YZI5_MOUSE UniProtKB/TrEMBL
  F6VK47_MOUSE UniProtKB/TrEMBL
  Q6P9L4 ENTREZGENE
  Q8BUQ6_MOUSE UniProtKB/TrEMBL
  UBP49_MOUSE UniProtKB/Swiss-Prot