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Gene: Serpina1e (serine (or cysteine) peptidase inhibitor, clade A, member 1E) Mus musculus
Symbol: Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Description: Predicted to have identical protein binding activity; protease binding activity; and serine-type endopeptidase inhibitor activity. Involved in response to cytokine and response to peptide hormone. Predicted to localize to the Golgi apparatus; endoplasmic reticulum; and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Is expressed in gut; liver lobe; metanephros; and nucleus pulposus. Orthologous to human SERPINA1 (serpin family A member 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-1 protease inhibitor 5; alpha-1-antitrypsin 1-5; Dom5; PI5; serine (or cysteine) proteinase inhibitor, clade A, member 1e; serine protease inhibitor 1-5; serine protease inhibitor A1e; serpin A1e; Spi1-5
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl12103,946,931 - 103,958,975 (-)Ensembl
GRCm3812103,946,931 - 103,956,897 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712105,185,141 - 105,195,107 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612104,347,981 - 104,357,947 (-)NCBImm8
Celera12105,163,634 - 105,173,624 (-)NCBICelera
Cytogenetic Map12 ENCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Serpina1e
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1614435
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.