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Gene: Serpina1b (serine (or cysteine) preptidase inhibitor, clade A, member 1B) Mus musculus
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Symbol: Serpina1b
Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including in utero embryonic development; protein N-linked glycosylation; and response to peptide hormone. Localizes to extracellular region. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Is expressed in gut; liver lobe; nucleus pulposus; and renal calyx. Orthologous to human SERPINA1 (serpin family A member 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AAT; alpha-1 protease inhibitor 2; alpha-1-antiproteinase; alpha-1-antitrypsin 1-2; D12Ucla2; Dom2; MGC117839; PI2; serine (or cysteine) proteinase inhibitor, clade A, member 1b; serine protease inhibitor 1-2; serine protease inhibitor A1b; serpin A1b; Spi1-2
Orthologs:
No known orthologs. homologs ...
Related Pseudogenes: Gm17042   Gm17043   Gm17198   Gm5656   Gm6918   Gm8893   Gm8895  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl12103,728,156 - 103,830,373 (-)EnsemblGRCm38mm10GRCm38
GRCm3812103,728,156 - 103,738,189 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712104,966,366 - 104,976,399 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612104,129,206 - 104,139,239 (-)NCBImm8
Celera12104,932,957 - 104,954,780 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Serpina1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1614438
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.