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Gene: Serpina1b (serine (or cysteine) preptidase inhibitor, clade A, member 1B) Mus musculus
Symbol: Serpina1b
Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including in utero embryonic development; protein N-linked glycosylation; and response to peptide hormone. Localizes to extracellular region. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Is expressed in gut; liver lobe; nucleus pulposus; and renal calyx. Orthologous to human SERPINA1 (serpin family A member 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AAT; alpha-1 protease inhibitor 2; alpha-1-antiproteinase; alpha-1-antitrypsin 1-2; D12Ucla2; Dom2; MGC117839; PI2; serine (or cysteine) proteinase inhibitor, clade A, member 1b; serine protease inhibitor 1-2; serine protease inhibitor A1b; serpin A1b; Spi1-2
No known orthologs. homologs ...
Related Pseudogenes: Gm17042   Gm17043   Gm17198   Gm5656   Gm6918   Gm8893   Gm8895  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl12103,728,156 - 103,830,373 (-)EnsemblGRCm38mm10GRCm38
GRCm3812103,728,156 - 103,738,189 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712104,966,366 - 104,976,399 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612104,129,206 - 104,139,239 (-)NCBImm8
Celera12104,932,957 - 104,954,780 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Serpina1b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1614438
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.