2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731405 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RAPGEF1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RAPGEF1 mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of RAPGEF1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731405 6480464 Tetrachlorodibenzodioxin results in increased expression of RAPGEF1 mRNA CTD PMID:19684285 2,6-dinitrotoluene affects expression ISO RGD:619793 6480464 2, 6-dinitrotoluene affects the expression of RAPGEF1 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:731405 6480464 beta-methylcholine affects the expression of RAPGEF1 mRNA CTD PMID:21179406 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of RAPGEF1 mRNA CTD PMID:18648102 4-vinylcyclohexene dioxide affects expression EXP 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of RAPGEF1 mRNA CTD PMID:20829426 aflatoxin B1 increases methylation ISO RGD:731405 6480464 Aflatoxin B1 results in increased methylation of RAPGEF1 intron CTD PMID:30157460 ammonium chloride affects expression ISO RGD:619793 6480464 Ammonium Chloride affects the expression of RAPGEF1 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:731405 6480464 Arsenic affects the methylation of RAPGEF1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:731405 6480464 Arsenic affects the methylation of RAPGEF1 gene CTD PMID:25304211 benzo[a]pyrene affects expression EXP 6480464 Benzo(a)pyrene affects the expression of RAPGEF1 mRNA CTD PMID:22342234 benzo[a]pyrene affects methylation ISO RGD:731405 6480464 Benzo(a)pyrene affects the methylation of RAPGEF1 intron CTD PMID:30157460 benzo[e]pyrene decreases methylation ISO RGD:731405 6480464 benzo(e)pyrene results in decreased methylation of RAPGEF1 intron CTD PMID:30157460 bisphenol A affects expression ISO RGD:619793 6480464 bisphenol A affects the expression of RAPGEF1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:731405 6480464 bisphenol A results in increased expression of RAPGEF1 mRNA CTD PMID:29275510 bisphenol A decreases expression ISO RGD:731405 6480464 bisphenol A results in decreased expression of RAPGEF1 mRNA CTD PMID:25912373 bortezomib decreases expression ISO RGD:731405 6480464 Bortezomib results in decreased expression of RAPGEF1 mRNA CTD PMID:20977926 Brodifacoum decreases expression ISO RGD:619793 6480464 bromfenacoum results in decreased expression of RAPGEF1 protein CTD PMID:28903499 cisplatin decreases expression ISO RGD:731405 6480464 Cisplatin results in decreased expression of RAPGEF1 mRNA CTD PMID:27594783 cycloheximide multiple interactions ISO RGD:731405 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of RAPGEF1 mRNA CTD PMID:19684285 cyclosporin A increases expression ISO RGD:731405 6480464 Cyclosporine results in increased expression of RAPGEF1 mRNA CTD PMID:20106945 dicrotophos increases expression ISO RGD:731405 6480464 dicrotophos results in increased expression of RAPGEF1 mRNA CTD PMID:28302478 doxorubicin decreases expression ISO RGD:731405 6480464 Doxorubicin results in decreased expression of RAPGEF1 mRNA CTD PMID:29803840 ethanol increases expression EXP 6480464 Ethanol results in increased expression of RAPGEF1 mRNA CTD PMID:30319688 flutamide increases expression ISO RGD:619793 6480464 Flutamide results in increased expression of RAPGEF1 mRNA CTD PMID:24136188 lead(0) increases expression ISO RGD:731405 6480464 Lead results in increased expression of RAPGEF1 mRNA CTD PMID:19921347 lead(0) affects expression ISO RGD:731405 6480464 Lead affects the expression of RAPGEF1 mRNA CTD PMID:28903495 lead(2+) increases expression ISO RGD:731405 6480464 Lead results in increased expression of RAPGEF1 mRNA CTD PMID:19921347 lead(2+) affects expression ISO RGD:731405 6480464 Lead affects the expression of RAPGEF1 mRNA CTD PMID:28903495 leflunomide increases expression ISO RGD:731405 6480464 leflunomide results in increased expression of RAPGEF1 mRNA CTD PMID:28988120 MeIQx decreases expression ISO RGD:731405 6480464 2-amino-3 more ... CTD PMID:20816883 mercury dichloride increases phosphorylation ISO RGD:731405 6480464 Mercuric Chloride results in increased phosphorylation of RAPGEF1 protein CTD PMID:14551197 methapyrilene decreases methylation ISO RGD:731405 6480464 Methapyrilene results in decreased methylation of RAPGEF1 intron CTD PMID:30157460 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of RAPGEF1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:731405 6480464 Acetaminophen results in increased expression of RAPGEF1 mRNA CTD PMID:29067470 PhIP decreases expression ISO RGD:731405 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of RAPGEF1 mRNA CTD PMID:20816883 rotenone increases expression ISO RGD:731405 6480464 Rotenone results in increased expression of RAPGEF1 mRNA CTD PMID:29955902 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of RAPGEF1 mRNA CTD PMID:30912803 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of RAPGEF1 mRNA CTD PMID:17963808 valproic acid affects splicing ISO RGD:619793 6480464 Valproic Acid affects the splicing of RAPGEF1 mRNA CTD PMID:29427782 valproic acid increases expression ISO RGD:731405 6480464 Valproic Acid results in increased expression of RAPGEF1 mRNA CTD PMID:23179753
Biological Process
activation of GTPase activity IGI MGI:MGI:104686 more ... 2290270 (MGI:MGI:5634599, PMID:25621495) MGI MGI:MGI:5634599 , PMID:25621495 blood vessel development IMP MGI:MGI:2445403 2290270 (MGI:MGI:2445332, PMID:12466202) MGI MGI:MGI:2445332 , PMID:12466202 cell-cell adhesion IMP MGI:MGI:2445403 2290270 (MGI:MGI:2445332, PMID:12466202) MGI MGI:MGI:2445332 , PMID:12466202 cellular response to cAMP ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cellular response to nerve growth factor stimulus ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 establishment of endothelial barrier ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of canonical Wnt signaling pathway IGI MGI:MGI:95516 2290270 (MGI:MGI:3701731, PMID:16858399) MGI MGI:MGI:3701731 , PMID:16858399 negative regulation of ERK1 and ERK2 cascade IGI MGI:MGI:95516 2290270 (MGI:MGI:3701731, PMID:16858399) MGI MGI:MGI:3701731 , PMID:16858399 negative regulation of neural precursor cell proliferation IMP MGI:MGI:2445403 2290270 (MGI:MGI:3701731, PMID:16858399) MGI MGI:MGI:3701731 , PMID:16858399 negative regulation of protein kinase B signaling IGI MGI:MGI:95516 2290270 (MGI:MGI:3701731, PMID:16858399) MGI MGI:MGI:3701731 , PMID:16858399 negative regulation of Ras protein signal transduction IMP MGI:MGI:2445403 2290270 (MGI:MGI:3701731, PMID:16858399) MGI MGI:MGI:3701731 , PMID:16858399 nerve growth factor signaling pathway ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 platelet-derived growth factor receptor signaling pathway IMP MGI:MGI:2445403 2290270 (MGI:MGI:2445332, PMID:12466202) MGI MGI:MGI:2445332 , PMID:12466202 positive regulation of ERK1 and ERK2 cascade ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of GTPase activity ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of neuron projection development ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of neuron projection development ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Rap protein signal transduction ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of cell junction assembly ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of JNK cascade ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868
Cellular Component
cytoplasm ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 early endosome ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 intracellular membrane-bounded organelle ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 perinuclear region of cytoplasm ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phagocytic vesicle membrane ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein-containing complex ISO RGD:619793 2290270 RGD GO_REF:0000096, MGI:MGI:4417868
Molecular Function
guanyl-nucleotide exchange factor activity IDA 2290270 (MGI:MGI:3032880 more ... MGI MGI:MGI:3032880 more ... protein binding IPI UniProtKB:P47941 2290270 (MGI:MGI:2665211, PMID:12697763) MGI MGI:MGI:2665211 , PMID:12697763 protein binding IPI UniProtKB:Q60631 2290270 (MGI:MGI:3688344, PMID:15102471) IntAct MGI:MGI:3688344 , PMID:15102471 protein binding IPI UniProtID:P47941 2290270 (MGI:MGI:3692090, PMID:12671687) MGI MGI:MGI:3692090 , PMID:12671687 Rap guanyl-nucleotide exchange factor activity ISO UniProtKB:Q13905 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SH3/SH2 adaptor activity TAS 2290270 (MGI:MGI:73867, PMID:7797522) MGI MGI:MGI:73867 , PMID:7797522