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Gene: Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1) Mus musculus
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Symbol: Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Description: Exhibits guanyl-nucleotide exchange factor activity. Involved in several processes, including activation of GTPase activity; negative regulation of signal transduction; and platelet-derived growth factor receptor signaling pathway. Predicted to localize to several cellular components, including the cytoplasmic vesicle; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; and liver. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4-vinylcyclohexene dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4932418O06Rik; C3G; Grf2; guanine nucleotide releasing factor 2; rap guanine nucleotide exchange factor 1
Orthologs:
Homo sapiens (human) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rapgef1 (Rap guanine nucleotide exchange factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
Sus scrofa (pig) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38229,619,720 - 29,740,364 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37229,475,240 - 29,595,883 (+)NCBIGRCm37mm9NCBIm37
MGSCv36229,441,729 - 29,562,372 (+)NCBImm8
Celera229,325,793 - 29,447,456 (+)NCBICelera
Cytogenetic Map2 BNCBI
cM Map220.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rapgef1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1614994
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.