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Gene: Flcn (folliculin) Mus musculus
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Symbol: Flcn
Name: folliculin
Description: Predicted to have GTPase activator activity. Involved in several processes, including negative regulation of cellular metabolic process; regulation of intracellular signal transduction; and regulation of protein modification process. Predicted to colocalize with cell-cell contact zone and midbody. Is expressed in several structures, including embryo ectoderm; exocrine gland; extraembryonic component; limb bud; and optic cup. Used to study Birt-Hogg-Dube syndrome and nonpapillary renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin); PARTICIPATES IN mTOR signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU014660; B430214A04Rik; Bhd; birt-Hogg-Dube syndrome protein homolog; FLCL; MGC37841
Orthologs:
Homo sapiens (human) : FLCN (folliculin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flcn (folliculin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flcn (folliculin)
Pan paniscus (bonobo/pygmy chimpanzee) : FLCN (folliculin)
Canis lupus familiaris (dog) : FLCN (folliculin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flcn (folliculin)
Sus scrofa (pig) : FLCN (folliculin)
Chlorocebus sabaeus (African green monkey) : FLCN (folliculin)
Heterocephalus glaber (naked mole-rat) : Flcn (folliculin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBImm8
MGSCv361160,328,330 - 60,346,353 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Flcn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1615711
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.