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Gene: Flcn (folliculin) Mus musculus
Symbol: Flcn
Name: folliculin
Description: Predicted to have GTPase activator activity. Involved in several processes, including negative regulation of cellular metabolic process; regulation of intracellular signal transduction; and regulation of protein modification process. Predicted to colocalize with cell-cell contact zone and midbody. Is expressed in several structures, including embryo ectoderm; exocrine gland; extraembryonic component; limb bud; and optic cup. Used to study Birt-Hogg-Dube syndrome and nonpapillary renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin); PARTICIPATES IN mTOR signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU014660; B430214A04Rik; Bhd; birt-Hogg-Dube syndrome protein homolog; FLCL; MGC37841
Homo sapiens (human) : FLCN (folliculin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flcn (folliculin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flcn (folliculin)
Pan paniscus (bonobo/pygmy chimpanzee) : FLCN (folliculin)
Canis lupus familiaris (dog) : FLCN (folliculin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flcn (folliculin)
Sus scrofa (pig) : FLCN (folliculin)
Chlorocebus sabaeus (African green monkey) : FLCN (folliculin)
Heterocephalus glaber (naked mole-rat) : Flcn (folliculin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBImm8
MGSCv361160,328,330 - 60,346,353 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Flcn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1615711
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.