Gene: Flrt1 (fibronectin leucine rich transmembrane protein 1) Mus musculus
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Symbol:
Flrt1
Name:
fibronectin leucine rich transmembrane protein 1
Description:
Exhibits fibroblast growth factor receptor binding activity. Involved in fibroblast growth factor receptor signaling pathway; neuron projection development; and positive regulation of synapse assembly. Localizes to several cellular components, including the neuron projection terminus; neuronal cell body membrane; and perinuclear region of cytoplasm. Colocalizes with the focal adhesion. Is expressed in several structures, including 3rd branchial arch; central nervous system; future brain; gut; and sensory organ. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1); INTERACTS WITH 3,3',5-triiodo-L-thyronine; benzo[a]pyrene; buta-1,3-diene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AW742165; D630040I23Rik; leucine-rich repeat transmembrane protein FLRT1; RIKEN cDNA D630040I23 gene
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
FLRT1 (fibronectin leucine rich transmembrane protein 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Flrt1 (fibronectin leucine rich transmembrane protein 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Flrt1 (fibronectin leucine rich transmembrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
FLRT1 (fibronectin leucine rich transmembrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
FLRT1 (fibronectin leucine rich transmembrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Flrt1 (fibronectin leucine rich transmembrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
FLRT1 (fibronectin leucine rich transmembrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
FLRT3 (fibronectin leucine rich transmembrane protein 3) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
FLRT1 (fibronectin leucine rich transmembrane protein 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Flrt1 (fibronectin leucine rich transmembrane protein 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
flrt1b (fibronectin leucine rich transmembrane protein 1b)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam, ZFIN)
Danio rerio (zebrafish):
flrt1a (fibronectin leucine rich transmembrane protein 1a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 19 7,087,464 - 7,166,183 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 7,166,491 - 7,180,219 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 7,162,028 - 7,172,725 (-) NCBI mm8 Celera 19 6,868,883 - 6,882,611 (-) NCBI Celera Cytogenetic Map 19 A NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1565152 6480464 Ethinyl Estradiol results in increased expression of FLRT1 mRNA CTD PMID:29097150 17beta-estradiol affects expression ISO RGD:1345456 6480464 Estradiol affects the expression of FLRT1 mRNA CTD PMID:14699072 3,3',5-triiodo-L-thyronine increases expression EXP 6480464 Triiodothyronine results in increased expression of FLRT1 mRNA CTD PMID:25172293 all-trans-retinoic acid decreases expression ISO RGD:1345456 6480464 Tretinoin results in decreased expression of FLRT1 mRNA CTD PMID:23724009 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to FLRT1 promoter] CTD PMID:19654925 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1565152 6480464 Diethylhexyl Phthalate results in decreased expression of FLRT1 mRNA CTD PMID:29945229 buta-1,3-diene decreases expression EXP 6480464 1, 3-butadiene results in decreased expression of FLRT1 mRNA CTD PMID:29038090 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of FLRT1 mRNA CTD PMID:25554681 cisplatin increases expression ISO RGD:1345456 6480464 Cisplatin results in increased expression of FLRT1 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1345456 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of FLRT1 mRNA CTD PMID:27392435 cyclosporin A increases expression ISO RGD:1345456 6480464 Cyclosporine results in increased expression of FLRT1 mRNA CTD PMID:20106945 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of FLRT1 mRNA CTD PMID:17361019 , PMID:21266533 dorsomorphin multiple interactions ISO RGD:1345456 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLRT1 mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:1345456 6480464 entinostat results in increased expression of FLRT1 mRNA CTD PMID:27188386 ethanol increases expression EXP 6480464 Ethanol results in increased expression of FLRT1 mRNA CTD PMID:30319688 furan decreases expression ISO RGD:1565152 6480464 furan results in decreased expression of FLRT1 mRNA CTD PMID:25539665 nickel atom decreases expression ISO RGD:1345456 6480464 Nickel results in decreased expression of FLRT1 mRNA CTD PMID:24768652 , PMID:25583101 raloxifene affects expression ISO RGD:1345456 6480464 Raloxifene Hydrochloride affects the expression of FLRT1 mRNA CTD PMID:14699072 SB 431542 multiple interactions ISO RGD:1345456 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLRT1 mRNA CTD PMID:27188386 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of FLRT1 mRNA CTD PMID:25123088 tamoxifen affects expression ISO RGD:1345456 6480464 Tamoxifen affects the expression of FLRT1 mRNA CTD PMID:14699072 trichloroethene increases methylation ISO RGD:1565152 6480464 Trichloroethylene results in increased methylation of FLRT1 gene CTD PMID:27618143 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of FLRT1 mRNA CTD PMID:28973375 trichostatin A increases expression ISO RGD:1345456 6480464 trichostatin A results in increased expression of FLRT1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1345456 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLRT1 mRNA CTD PMID:27188386 triclosan increases expression ISO RGD:1345456 6480464 Triclosan results in increased expression of FLRT1 mRNA CTD PMID:30510588 valproic acid affects expression ISO RGD:1345456 6480464 Valproic Acid affects the expression of FLRT1 mRNA CTD PMID:25979313 
Gene-Chemical Interaction Annotations
