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Gene: Wnk1 (WNK lysine deficient protein kinase 1) Mus musculus
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Symbol: Wnk1
Name: WNK lysine deficient protein kinase 1
CRRD ID: 1616541
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; lymphocyte migration into lymph node; and protein phosphorylation. Localizes to cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1); PARTICIPATES IN Erk5 MAPK signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acetazolamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6430573H23Rik; EG406236; hereditary sensory neuropathy, type II; Hs; Hsn2; MGC175896; MGC175898; mKIAA0344; Prkw; Prkwnk1; protein kinase lysine-deficient 1; protein kinase with no lysine 1; serine/threonine-protein kinase WNK1
Orthologs:
Homo sapiens (human) : WNK1 (WNK lysine deficient protein kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Wnk1 (WNK lysine deficient protein kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wnk1 (WNK lysine deficient protein kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : WNK1 (WNK lysine deficient protein kinase 1)
Canis lupus familiaris (dog) : WNK1 (WNK lysine deficient protein kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wnk1 (WNK lysine deficient protein kinase 1)
Sus scrofa (pig) : WNK1 (WNK lysine deficient protein kinase 1)
Chlorocebus sabaeus (African green monkey) : WNK1 (WNK lysine deficient protein kinase 1)
Heterocephalus glaber (naked mole-rat) : Wnk1 (WNK lysine deficient protein kinase 1)
more info ...
Related Pseudogenes: Gm18784  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,900,930 - 120,015,659 (-)NCBI
GRCm386119,923,969 - 120,038,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,923,969 - 120,038,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,873,987 - 119,988,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv366119,889,957 - 120,003,398 (-)NCBImm8
Celera6121,760,900 - 121,876,945 (-)NCBICelera
Cytogenetic Map6F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Wnk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1616541
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.