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Gene: Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) Mus musculus
Symbol: Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Description: Exhibits transmembrane signaling receptor activity. Involved in several processes, including animal organ development; regulation of gene expression; and regulation of signal transduction. Localizes to the integral component of plasma membrane. Used to study glaucoma. Human ortholog(s) of this gene implicated in osteoporosis. Is expressed in several structures, including alimentary system; eye; liver; metanephros; and testis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 1,1-dichloroethene; 4-hydroxyphenyl retinamide; 5-fluorouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9130225G07; A330106J01Rik; A930009A08Rik; G protein-coupled receptor 48; G protein-coupled receptor GPR48; G-protein coupled receptor 48; Gpr48; leucine-rich repeat-containing G-protein coupled receptor 4; RIKEN cDNA A330106J01 gene
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIGRCm37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBImm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2 E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Lgr4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1616653
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.