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Gene: Hells (helicase, lymphoid specific) Mus musculus
Symbol: Hells
Name: helicase, lymphoid specific
Description: Exhibits chromatin binding activity. Involved in several processes, including DNA metabolic process; cellular response to leukemia inhibitory factor; and chromatin organization involved in negative regulation of transcription. Localizes to nucleus and pericentric heterochromatin. Is expressed in several structures, including central nervous system; gut; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific); INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1,4-dioxane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323785; E130115I21Rik; LSH; lymphocyte-specific helicase; Lysh; PASG; proliferation-associated SNF2-like protein; YFK8
Homo sapiens (human) : HELLS (helicase, lymphoid specific)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hells (helicase, lymphoid specific)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hells (helicase, lymphoid specific)
Pan paniscus (bonobo/pygmy chimpanzee) : HELLS (helicase, lymphoid specific)
Canis lupus familiaris (dog) : HELLS (helicase, lymphoid specific)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hells (helicase, lymphoid specific)
Sus scrofa (pig) : HELLS (helicase, lymphoid specific)
Chlorocebus sabaeus (African green monkey) : HELLS (helicase, lymphoid specific)
Heterocephalus glaber (naked mole-rat) : Hells (helicase, lymphoid specific)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1938,930,915 - 38,971,051 (+)EnsemblGRCm38mm10GRCm38
GRCm381938,930,262 - 38,970,470 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371939,005,480 - 39,042,767 (+)NCBIGRCm37mm9NCBIm37
MGSCv361938,996,134 - 39,033,421 (+)NCBImm8
Celera1939,732,380 - 39,769,659 (+)NCBICelera
Cytogenetic Map19C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hells
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1616865
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.