Morc2b (microrchidia 2B) - Chinchilla Research Resource Database
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Gene: Morc2b (microrchidia 2B) Mus musculus
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Symbol: Morc2b
Name: microrchidia 2B
CRRD ID: 1617325
Description: Predicted to have ATP binding activity; hydrolase activity; and zinc ion binding activity. Involved in double-strand break repair involved in meiotic recombination; gamete generation; and homologous chromosome pairing at meiosis. Localizes to nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4932411A10Rik; ATPase MORC2B; MORC family CW-type zinc finger protein 2B; Morc-like protein; Tce6
Orthologs:
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,354,562 - 33,369,473 (-)NCBI
GRCm381733,135,588 - 33,150,499 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,113,351 - 33,139,683 (-)EnsemblGRCm38mm10GRCm38
MGSCv371733,272,535 - 33,276,628 (-)NCBIGRCm37mm9NCBIm37
MGSCv361732,872,400 - 32,876,675 (-)NCBImm8
Celera1734,041,539 - 34,045,632 (-)NCBICelera
Cytogenetic Map17B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IMP)

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15112104   PMID:16141072   PMID:16141073   PMID:16292313   PMID:21267068   PMID:21873635  
PMID:29329290  


Genomics


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
11038694Pas19_mpulmonary adenoma susceptibility 19 (mouse)172949219034535463Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173184267837333884Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173244145235301060Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:160
Interacting mature miRNAs:170
Transcripts:ENSMUST00000053896, ENSMUST00000131954
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000053896   ⟹   ENSMUSP00000056879
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1733,135,588 - 33,139,683 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131954   ⟹   ENSMUSP00000123354
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1733,135,643 - 33,139,499 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234062
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1733,113,351 - 33,139,632 (-)Ensembl
RefSeq Acc Id: NM_001360203   ⟹   NP_001347132
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,564 - 33,367,723 (-)NCBI
GRCm381733,135,590 - 33,148,749 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177719   ⟹   NP_808387
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,564 - 33,358,657 (-)NCBI
GRCm381733,135,590 - 33,139,683 (-)NCBI
MGSCv371733,272,535 - 33,276,628 (-)RGD
Celera1734,041,539 - 34,045,632 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524257   ⟹   XP_006524320
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,562 - 33,359,025 (-)NCBI
GRCm381733,135,588 - 33,140,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006524258   ⟹   XP_006524321
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,562 - 33,359,025 (-)NCBI
GRCm381733,135,588 - 33,140,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246444   ⟹   XP_011244746
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391733,354,562 - 33,369,473 (-)NCBI
GRCm381733,135,588 - 33,150,499 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_808387   ⟸   NM_177719
- UniProtKB: Q8C5W4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006524321   ⟸   XM_006524258
- Peptide Label: isoform X1
- UniProtKB: Q8C5W4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006524320   ⟸   XM_006524257
- Peptide Label: isoform X1
- UniProtKB: Q8C5W4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011244746   ⟸   XM_011246444
- Peptide Label: isoform X1
- UniProtKB: Q8C5W4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001347132   ⟸   NM_001360203
RefSeq Acc Id: ENSMUSP00000056879   ⟸   ENSMUST00000053896
RefSeq Acc Id: ENSMUSP00000123354   ⟸   ENSMUST00000131954
Protein Domains
CW-type

Promoters
RGD ID:13675558
Promoter ID:EPDNEW_M21928
Type:initiation region
Name:Morc2b_1
Description:Mus musculus microrchidia 2B , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381733,139,632 - 33,139,692EPDNEW
RGD ID:6828369
Promoter ID:MM_KWN:23087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000087649,   OTTMUST00000082308,   OTTMUST00000082309
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361733,276,446 - 33,276,946 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045293 AgrOrtholog
Ensembl Genes ENSMUSG00000048602 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000056879 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123354 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053896 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131954 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Morc_S5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:240069 UniProtKB/Swiss-Prot
MGD MGI:3045293 ENTREZGENE
NCBI Gene 240069 ENTREZGENE
Pfam Morc6_S5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Morc2b PhenoGen
PROSITE ZF_CW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.157765 ENTREZGENE
UniProt MOR2B_MOUSE UniProtKB/Swiss-Prot
  Q0VAW0_MOUSE UniProtKB/TrEMBL
  Q8C5W4 ENTREZGENE
UniProt Secondary B8JK02 UniProtKB/Swiss-Prot
  Q8CG24 UniProtKB/Swiss-Prot