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Gene: Tdp1 (tyrosyl-DNA phosphodiesterase 1) Mus musculus
Symbol: Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Description: Predicted to have 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Involved in single strand break repair. Localizes to the nucleus. Used to study spinocerebellar ataxia type 1 with axonal neuropathy. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810481F14Rik; 4921509N21Rik; AI838772; AW493413; E430034L06Rik; MLZ-501; protein expressed in male leptotene and zygotene spermatocytes 501; SCAN1; tyr-DNA phosphodiesterase 1; tyrosyl-DNA phodphodiesterase 1
Homo sapiens (human) : TDP1 (tyrosyl-DNA phosphodiesterase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Canis lupus familiaris (dog) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)
Sus scrofa (pig) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Chlorocebus sabaeus (African green monkey) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Heterocephalus glaber (naked mole-rat) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1299,884,517 - 99,955,219 (+)Ensembl
GRCm381299,884,463 - 99,955,223 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712101,122,725 - 101,193,429 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612100,285,568 - 100,338,412 (+)NCBImm8
Celera12101,107,017 - 101,181,494 (+)NCBICelera
Cytogenetic Map12 ENCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tdp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1617429
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.