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Gene: Tdp1 (tyrosyl-DNA phosphodiesterase 1) Mus musculus
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Symbol: Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Description: Predicted to have 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Involved in single strand break repair. Localizes to the nucleus. Used to study spinocerebellar ataxia type 1 with axonal neuropathy. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810481F14Rik; 4921509N21Rik; AI838772; AW493413; E430034L06Rik; MLZ-501; protein expressed in male leptotene and zygotene spermatocytes 501; SCAN1; tyr-DNA phosphodiesterase 1; tyrosyl-DNA phodphodiesterase 1
Orthologs:
Homo sapiens (human) : TDP1 (tyrosyl-DNA phosphodiesterase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Canis lupus familiaris (dog) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)
Sus scrofa (pig) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Chlorocebus sabaeus (African green monkey) : TDP1 (tyrosyl-DNA phosphodiesterase 1)
Heterocephalus glaber (naked mole-rat) : Tdp1 (tyrosyl-DNA phosphodiesterase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1299,884,517 - 99,955,219 (+)Ensembl
GRCm381299,884,463 - 99,955,223 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712101,122,725 - 101,193,429 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612100,285,568 - 100,338,412 (+)NCBImm8
Celera12101,107,017 - 101,181,494 (+)NCBICelera
Cytogenetic Map12 ENCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tdp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1617429
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.