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Gene: Tdgf1 (teratocarcinoma-derived growth factor 1) Mus musculus
Symbol: Tdgf1
Name: teratocarcinoma-derived growth factor 1
Description: Exhibits several functions, including Wnt-protein binding activity; nodal binding activity; and type I activin receptor binding activity. Involved in several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and nodal signaling pathway. Localizes to several cellular components, including the Golgi apparatus; extrinsic component of plasma membrane; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Is expressed in several structures, including blastocyst; brain; embryo mesoderm; extraembryonic component; and heart. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1); PARTICIPATES IN glypican signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 5-fluorouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CR1; cripto; cripto growth factor; epidermal growth factor-like Cripto protein; teratocarcinoma-derived growth factor; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
Homo sapiens (human) : TDGF1 (teratocarcinoma-derived growth factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tdgf1 (teratocarcinoma-derived growth factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdgf1 (teratocarcinoma-derived growth factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TDGF1 (teratocarcinoma-derived growth factor 1)
Canis lupus familiaris (dog) : TDGF1 (teratocarcinoma-derived growth factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdgf1 (teratocarcinoma-derived growth factor 1)
Sus scrofa (pig) : TDGF1 (teratocarcinoma-derived growth factor 1)
Chlorocebus sabaeus (African green monkey) : TDGF1 (teratocarcinoma-derived growth factor 1)
Heterocephalus glaber (naked mole-rat) : Tdgf1 (teratocarcinoma-derived growth factor 1)
more info ...
Related Pseudogenes: Tdgf1-ps1   Tdgf1-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl9110,939,603 - 110,946,158 (-)Ensembl
GRCm389110,939,608 - 110,946,158 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379110,842,112 - 110,848,662 (-)NCBIGRCm37mm9NCBIm37
MGSCv369110,784,418 - 110,790,883 (-)NCBImm8
Celera9110,664,719 - 110,671,594 (-)NCBICelera
Cytogenetic Map9 F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tdgf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1617601
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.