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Gene: Tdgf1 (teratocarcinoma-derived growth factor 1) Mus musculus
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Symbol: Tdgf1
Name: teratocarcinoma-derived growth factor 1
Description: Exhibits several functions, including Wnt-protein binding activity; nodal binding activity; and type I activin receptor binding activity. Involved in several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and nodal signaling pathway. Localizes to several cellular components, including the Golgi apparatus; extrinsic component of plasma membrane; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Is expressed in several structures, including blastocyst; brain; embryo mesoderm; extraembryonic component; and heart. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1); PARTICIPATES IN glypican signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 5-fluorouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CR1; cripto; cripto growth factor; epidermal growth factor-like Cripto protein; teratocarcinoma-derived growth factor; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
Orthologs:
Homo sapiens (human) : TDGF1 (teratocarcinoma-derived growth factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tdgf1 (teratocarcinoma-derived growth factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdgf1 (teratocarcinoma-derived growth factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TDGF1 (teratocarcinoma-derived growth factor 1)
Canis lupus familiaris (dog) : TDGF1 (teratocarcinoma-derived growth factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdgf1 (teratocarcinoma-derived growth factor 1)
Sus scrofa (pig) : TDGF1 (teratocarcinoma-derived growth factor 1)
Chlorocebus sabaeus (African green monkey) : TDGF1 (teratocarcinoma-derived growth factor 1)
Heterocephalus glaber (naked mole-rat) : Tdgf1 (teratocarcinoma-derived growth factor 1)
more info ...
Related Pseudogenes: Tdgf1-ps1   Tdgf1-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl9110,939,603 - 110,946,158 (-)Ensembl
GRCm389110,939,608 - 110,946,158 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379110,842,112 - 110,848,662 (-)NCBIGRCm37mm9NCBIm37
MGSCv369110,784,418 - 110,790,883 (-)NCBImm8
Celera9110,664,719 - 110,671,594 (-)NCBICelera
Cytogenetic Map9 F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tdgf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1617601
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.