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Gene: Itgav (integrin alpha V) Mus musculus
Symbol: Itgav
Name: integrin alpha V
Description: Exhibits integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Localizes to the external side of plasma membrane; integrin alphav-beta5 complex; and integrin alphav-beta6 complex. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Is expressed in several structures, including alimentary system; embryo mesenchyme; extraembryonic component; skeletal muscle; and ventricular layer. Orthologous to human ITGAV (integrin subunit alpha V).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110004F14Rik; 2610028E01Rik; alpha v integrin; alphav-integrin; CD51; D430040G12Rik; integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha
Homo sapiens (human) : ITGAV (integrin subunit alpha V)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgav (integrin subunit alpha V)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgav (integrin subunit alpha V)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGAV (integrin subunit alpha V)
Canis lupus familiaris (dog) : ITGAV (integrin subunit alpha V)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgav (integrin subunit alpha V)
Sus scrofa (pig) : ITGAV (integrin subunit alpha V)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl283,724,397 - 83,806,916 (+)Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBImm8
Celera285,367,604 - 85,456,007 (+)NCBICelera
Cytogenetic Map2 DNCBI
cM Map249.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itgav
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1617623
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.