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Gene: Itgav (integrin alpha V) Mus musculus
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Symbol: Itgav
Name: integrin alpha V
Description: Exhibits integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Localizes to the external side of plasma membrane; integrin alphav-beta5 complex; and integrin alphav-beta6 complex. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Is expressed in several structures, including alimentary system; embryo mesenchyme; extraembryonic component; skeletal muscle; and ventricular layer. Orthologous to human ITGAV (integrin subunit alpha V).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110004F14Rik; 2610028E01Rik; alpha v integrin; alphav-integrin; CD51; D430040G12Rik; integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha
Orthologs:
Homo sapiens (human) : ITGAV (integrin subunit alpha V)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgav (integrin subunit alpha V)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgav (integrin subunit alpha V)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGAV (integrin subunit alpha V)
Canis lupus familiaris (dog) : ITGAV (integrin subunit alpha V)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgav (integrin subunit alpha V)
Sus scrofa (pig) : ITGAV (integrin subunit alpha V)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl283,724,397 - 83,806,916 (+)Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBImm8
Celera285,367,604 - 85,456,007 (+)NCBICelera
Cytogenetic Map2 DNCBI
cM Map249.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Itgav
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1617623
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.