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Gene: Aph1c (aph1 homolog C, gamma secretase subunit) Mus musculus
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Symbol: Aph1c
Name: aph1 homolog C, gamma secretase subunit
Description: Exhibits endopeptidase activity. Involved in metanephros development and protein processing. Predicted to localize to the endoplasmic reticulum; gamma-secretase complex; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Is expressed in brain and genitourinary system. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit); PARTICIPATES IN Alzheimer's disease pathway; Notch signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; silicon dioxide; titanium dioxide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 0610008A10Rik; anterior pharynx defective 1b; anterior pharynx defective 1c homolog; APH-1b; Aph1b; putative gamma-secretase subunit APH-1C
Orthologs:
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl966,814,994 - 66,834,726 (-)Ensembl
GRCm38966,814,991 - 66,834,706 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37966,662,801 - 66,682,513 (-)NCBIGRCm37mm9NCBIm37
MGSCv36966,614,138 - 66,633,850 (-)NCBImm8
Celera964,049,206 - 64,068,919 (-)NCBICelera
Cytogenetic Map9 CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Aph1c
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1618362
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.