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Gene: H2-Q2 (histocompatibility 2, Q region locus 2) Mus musculus
Symbol: H2-Q2
Name: histocompatibility 2, Q region locus 2
CRRD ID: 1618431
Description: Predicted to have several functions, including TAP complex binding activity; beta-2-microglobulin binding activity; and signaling receptor binding activity. Involved in female pregnancy and growth. Predicted to localize to several cellular components, including Golgi medial cisterna; MHC class I protein complex; and endoplasmic reticulum. Is expressed in brain; small intestine; and thymus. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BE136769; class Ib major histocompatibility complex; ENSMUSG00000079507; expressed sequence BE136769; Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1; MHC class II antigen D; MHC class II antigen K; MHC classIb like protein GS14-2
No known orthologs. homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,561,283 - 35,565,740 (+)NCBI
GRCm381735,342,307 - 35,346,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,342,242 - 35,346,762 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,479,278 - 35,482,667 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,950,386 - 34,953,775 (+)NCBImm8
Celera1738,424,425 - 38,427,814 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on H2-Q2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1618431
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.