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Gene: H2-Q1 (histocompatibility 2, Q region locus 1) Mus musculus
Symbol: H2-Q1
Name: histocompatibility 2, Q region locus 1
CRRD ID: 1618432
Description: Predicted to have several functions, including TAP complex binding activity; beta-2-microglobulin binding activity; and signaling receptor binding activity. Involved in antigen processing and presentation. Predicted to localize to several cellular components, including Golgi medial cisterna; MHC class I protein complex; and endoplasmic reticulum. Is expressed in brain; small intestine; and thymus. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; antigen processing and presentation pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2Q1; H2-D1; MGC91064; MHC class II antigen D; Q1; Q1b; Q1d; Q1k; Qa-1; Qa1; Qed-1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,539,503 - 35,547,118 (+)NCBI
GRCm381735,320,525 - 35,328,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,320,405 - 35,325,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,457,503 - 35,462,044 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,433,669 - 34,438,526 (+)NCBImm8
MGSCv361734,928,615 - 34,933,472 (+)NCBImm8
Cytogenetic Map17B1NCBI
cM Map1718.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-Q1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1618432
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.