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Gene: Sesn2 (sestrin 2) Mus musculus
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Symbol: Sesn2
Name: sestrin 2
Description: Exhibits GDP-dissociation inhibitor activity. Involved in several processes, including intracellular signal transduction; negative regulation of TORC1 signaling; and regulation of cellular protein metabolic process. Colocalizes with the TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2); PARTICIPATES IN mTOR signaling pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 2-amino-2-deoxy-D-galactopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: HI95; MGC11758; Ses2; SEST2; sestrin-2
Orthologs:
Homo sapiens (human) : SESN2 (sestrin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sesn2 (sestrin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sesn2 (sestrin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SESN2 (sestrin 2)
Canis lupus familiaris (dog) : SESN2 (sestrin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sesn2 (sestrin 2)
Sus scrofa (pig) : SESN2 (sestrin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm384132,492,804 - 132,510,456 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374132,048,719 - 132,066,371 (-)NCBIGRCm37mm9NCBIm37
MGSCv364131,764,880 - 131,782,532 (-)NCBImm8
Celera4130,652,973 - 130,670,713 (-)NCBICelera
Cytogenetic Map4 D2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Sesn2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1618969
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.