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Gene: H2-M2 (histocompatibility 2, M region locus 2) Mus musculus
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Symbol: H2-M2
Name: histocompatibility 2, M region locus 2
Description: Predicted to have peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Localizes to the cell surface. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; asthma (multiple); bone inflammation disease (multiple); eye disease (multiple); and inner ear disease (multiple). Is expressed in thymus. Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; abacavir; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2M2; Thy19.4
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381737,480,851 - 37,483,554 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371737,617,796 - 37,620,474 (-)NCBIGRCm37mm9NCBIm37
MGSCv361737,088,904 - 37,091,582 (-)NCBImm8
Celera1740,921,406 - 40,924,072 (-)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1719.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on H2-M2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1619261
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.