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Gene: H2-D1 (histocompatibility 2, D region locus 1) Mus musculus
Symbol: H2-D1
Name: histocompatibility 2, D region locus 1
CRRD ID: 1619267
Description: Predicted to have several functions, including TAP complex binding activity; beta-2-microglobulin binding activity; and signaling receptor binding activity. Involved in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; negative regulation of neuron projection development; and positive regulation of T cell mediated cytotoxicity. Localizes to external side of plasma membrane. Colocalizes with membrane raft. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: class I major histocompatability complex; H-2 class I histocompatibility antigen, D-B alpha chain; H-2 class I histocompatibility antigen, L-D alpha chain; H-2D; H-2D cell surface glycoprotein; H2-D; H2-DC1-beta transplantation antigen protein; H2-K1; MHC class I antigen; MHC class I H-2Dp; MHC class I H2 antigen; MHC H2-D-q alpha-chain; Q5k protein
Rattus norvegicus (Norway rat) : RT1-A2 (RT1 class Ia, locus A2)  Alliance
more info ...
Related Pseudogenes: Gm20950   H2-Q3  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,482,070 - 35,486,473 (+)NCBI
GRCm381735,263,094 - 35,267,497 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,262,730 - 35,267,499 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,400,039 - 35,404,442 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,871,167 - 34,875,408 (+)NCBImm8
MGSCv361734,376,195 - 34,380,445 (+)NCBImm8
Cytogenetic Map17B1NCBI
cM Map1718.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-D1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1619267
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.