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Gene: Casq1 (calsequestrin 1) Mus musculus
Symbol: Casq1
Name: calsequestrin 1
Description: Exhibits calcium ion binding activity. Involved in several processes, including regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; response to heat; and sarcomere organization. Localizes to the mitochondrial matrix and sarcoplasmic reticulum lumen. Predicted to colocalize with the Golgi apparatus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including diaphragm; heart; lung; myotome; and skeletal muscle. Orthologous to human CASQ1 (calsequestrin 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 3,4-methylenedioxymethamphetamine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calmitine; calsequestrin, skeletal muscle isoform; calsequestrin-1; CSQ; CSQ-1; CSQ1; sCSQ
Homo sapiens (human) : CASQ1 (calsequestrin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casq1 (calsequestrin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casq1 (calsequestrin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CASQ1 (calsequestrin 1)
Canis lupus familiaris (dog) : CASQ1 (calsequestrin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casq1 (calsequestrin 1)
Sus scrofa (pig) : CASQ1 (calsequestrin 1)
Chlorocebus sabaeus (African green monkey) : CASQ1 (calsequestrin 1)
Heterocephalus glaber (naked mole-rat) : Casq1 (calsequestrin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1172,209,894 - 172,219,868 (-)EnsemblGRCm38mm10GRCm38
GRCm381172,209,894 - 172,219,895 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371174,140,025 - 174,150,026 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,047,013 - 174,056,514 (-)NCBImm8
Celera1175,065,863 - 175,075,868 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Casq1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1619288
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.