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Gene: Sppl3 (signal peptide peptidase 3) Mus musculus
Symbol: Sppl3
Name: signal peptide peptidase 3
CRRD ID: 1620736
Description: Predicted to have aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cytosolic calcium ion concentration. Localizes to endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in central nervous system; gonad; retina; and vibrissa. Orthologous to human SPPL3 (signal peptide peptidase like 3); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4833416I09Rik; IMP-2; intramembrane protease 2; MGC90867; presenilin-like protein 4; Psl4; signal peptide peptidase-like 3; SPP-like 3 protein; upregulated during skeletal muscle growth 3; Usmg; Usmg3
Homo sapiens (human) : SPPL3 (signal peptide peptidase like 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sppl3 (signal peptide peptidase like 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl3 (signal peptide peptidase like 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL3 (signal peptide peptidase like 3)
Canis lupus familiaris (dog) : SPPL3 (signal peptide peptidase like 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl3 (signal peptide peptidase like 3)
Sus scrofa (pig) : SPPL3 (signal peptide peptidase like 3)
Chlorocebus sabaeus (African green monkey) : SPPL3 (signal peptide peptidase like 3)
Heterocephalus glaber (naked mole-rat) : Sppl3 (signal peptide peptidase like 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5115,011,137 - 115,098,790 (+)EnsemblGRCm38mm10GRCm38
GRCm385115,011,524 - 115,098,790 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375115,461,533 - 115,548,799 (+)NCBIGRCm37mm9NCBIm37
MGSCv365115,272,523 - 115,359,789 (+)NCBImm8
Celera5112,107,828 - 112,194,819 (+)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sppl3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1620736
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.