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Gene: Sppl3 (signal peptide peptidase 3) Mus musculus
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Symbol: Sppl3
Name: signal peptide peptidase 3
CRRD ID: 1620736
Description: Predicted to have aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cytosolic calcium ion concentration. Localizes to endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in central nervous system; gonad; retina; and vibrissa. Orthologous to human SPPL3 (signal peptide peptidase like 3); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4833416I09Rik; IMP-2; intramembrane protease 2; MGC90867; presenilin-like protein 4; Psl4; signal peptide peptidase-like 3; SPP-like 3 protein; upregulated during skeletal muscle growth 3; Usmg; Usmg3
Orthologs:
Homo sapiens (human) : SPPL3 (signal peptide peptidase like 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sppl3 (signal peptide peptidase like 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl3 (signal peptide peptidase like 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL3 (signal peptide peptidase like 3)
Canis lupus familiaris (dog) : SPPL3 (signal peptide peptidase like 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl3 (signal peptide peptidase like 3)
Sus scrofa (pig) : SPPL3 (signal peptide peptidase like 3)
Chlorocebus sabaeus (African green monkey) : SPPL3 (signal peptide peptidase like 3)
Heterocephalus glaber (naked mole-rat) : Sppl3 (signal peptide peptidase like 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5115,011,137 - 115,098,790 (+)EnsemblGRCm38mm10GRCm38
GRCm385115,011,524 - 115,098,790 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375115,461,533 - 115,548,799 (+)NCBIGRCm37mm9NCBIm37
MGSCv365115,272,523 - 115,359,789 (+)NCBImm8
Celera5112,107,828 - 112,194,819 (+)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Sppl3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1620736
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.