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Gene: C9orf72 (C9orf72, member of C9orf72-SMCR8 complex) Mus musculus
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Symbol: C9orf72
Name: C9orf72, member of C9orf72-SMCR8 complex
CRRD ID: 1620759
Description: Exhibits Rab GTPase binding activity. Predicted to contribute to Rab guanyl-nucleotide exchange factor activity. Involved in several processes, including axon extension; late endosome to lysosome transport; and negative regulation of GTP binding activity. Localizes to several cellular components, including extracellular space; neuron projection; and perikaryon. Predicted to colocalize with Atg1/ULK1 kinase complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study autoimmune hypersensitivity disease. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-1. Orthologous to human C9orf72 (C9orf72-SMCR8 complex subunit); INTERACTS WITH 1,2-dimethylhydrazine; ethanol; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3110043O21Rik; AI840585; Denn; Dennd9; guanine nucleotide exchange C9orf72 homolog; hypothetical protein LOC73205; protein C9orf72 homolog; RIKEN cDNA 3110043O21 gene; RP23-307M2.1; uncharacterized protein C9orf72 homolog
Orthologs:
Homo sapiens (human) : C9orf72 (C9orf72-SMCR8 complex subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : RGD1359108 (similar to RIKEN cDNA 3110043O21)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C9orf72 (C9orf72-SMCR8 complex subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : C9orf72 (C9orf72-SMCR8 complex subunit)
Canis lupus familiaris (dog) : C11H9orf72 (chromosome 11 C9orf72 homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C9orf72 (C9orf72-SMCR8 complex subunit)
Sus scrofa (pig) : C10H9orf72 (chromosome 10 C9orf72 homolog)
Chlorocebus sabaeus (African green monkey) : C9orf72 (C9orf72-SMCR8 complex subunit)
Heterocephalus glaber (naked mole-rat) : C9orf72 (C9orf72-SMCR8 complex subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl435,191,285 - 35,226,175 (-)EnsemblGRCm38mm10GRCm38
GRCm38435,191,285 - 35,226,153 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37435,138,531 - 35,173,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv36435,380,169 - 35,415,010 (-)NCBImm8
Celera434,907,703 - 34,942,307 (-)NCBICelera
Cytogenetic Map4A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on C9orf72
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1620759
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.