Gene: Zfp593 (zinc finger protein 593) Mus musculus
Analyze
Symbol:
Zfp593
Name:
zinc finger protein 593
Description:
Predicted to have ribosomal large subunit binding activity and zinc ion binding activity. Predicted to be involved in negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; positive regulation of transcription by RNA polymerase II; and ribosomal large subunit export from nucleus. Predicted to localize to the nucleolus; nucleoplasm; and preribosome, large subunit precursor. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and submandibular gland primordium. Orthologous to human ZNF593 (zinc finger protein 593); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
3110024A21Rik; AV062409; E130106C14Rik; RP23-354H24.5; zinc finger protein T86; ZNF593
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ZNF593 (zinc finger protein 593) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Zfp593 (zinc finger protein 593) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Znf593 (zinc finger protein 593) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ZNF593 (zinc finger protein 593) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ZNF593 (zinc finger protein 593) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Znf593 (zinc finger protein 593) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ZNF593 (zinc finger protein 593) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Zfp593 (zinc finger protein 593)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ZNF593 (zinc finger protein 593)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
znf593 (zinc finger protein 593)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
BUD20
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
CG3224
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
Y56A3A.18
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 4 134,243,306 - 134,245,591 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 4 133,799,221 - 133,801,506 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 4 133,515,382 - 133,517,604 (-) NCBI mm8 Celera 4 132,423,098 - 132,425,387 (-) NCBI Celera Cytogenetic Map 4 D3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-catechin increases expression ISO RGD:1320928 6480464 Catechin results in increased expression of ZNF593 mRNA CTD PMID:15465739 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of ZFP593 mRNA CTD PMID:17555576 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of ZNF593 mRNA CTD PMID:25210133 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ZFP593 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1310179 6480464 2, 4-dinitrotoluene affects the expression of ZNF593 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1310179 6480464 2, 6-dinitrotoluene affects the expression of ZNF593 mRNA CTD PMID:21346803 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of ZFP593 mRNA CTD PMID:25172293 4-amino-2,6-dinitrotoluene affects expression ISO RGD:1310179 6480464 4-amino-2, 6-dinitrotoluene affects the expression of ZNF593 mRNA CTD PMID:21346803 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ZFP593 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1320928 6480464 Aflatoxin B1 results in increased methylation of ZNF593 gene CTD PMID:27153756 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to ZFP593 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:1320928 6480464 Benzo(a)pyrene results in increased expression of ZNF593 mRNA CTD PMID:21632981 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of ZFP593 mRNA CTD PMID:22228805 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ZFP593 mRNA CTD PMID:26063408 , PMID:30245210 bisphenol A affects expression ISO RGD:1320928 6480464 bisphenol A affects the expression of ZNF593 mRNA CTD PMID:30903817 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of ZFP593 promoter CTD PMID:27312807 bisphenol A increases expression ISO RGD:1310179 6480464 bisphenol A results in increased expression of ZNF593 mRNA CTD PMID:25181051 butanal increases expression ISO RGD:1320928 6480464 butyraldehyde results in increased expression of ZNF593 mRNA CTD PMID:26079696 cadmium dichloride decreases methylation ISO RGD:1310179 6480464 Cadmium Chloride results in decreased methylation of ZNF593 promoter CTD PMID:22457795 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of ZFP593 mRNA, Nanotubes, Carbon results in increased expression of ZFP593 mRNA CTD PMID:25554681 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of ZFP593 mRNA CTD PMID:28472532 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of ZFP593 mRNA CTD PMID:25270620 coumarin increases expression ISO RGD:1310179 6480464 coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 cyclosporin A increases expression ISO RGD:1320928 6480464 Cyclosporine results in increased expression of ZNF593 mRNA CTD PMID:20106945 , PMID:25562108 cylindrospermopsin increases expression ISO RGD:1320928 6480464 cylindrospermopsin results in increased expression of ZNF593 mRNA CTD PMID:24921660 decabromodiphenyl ether increases expression ISO RGD:1310179 6480464 decabromobiphenyl ether results in increased expression of ZNF593 mRNA CTD PMID:23914054 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ZFP593 mRNA CTD PMID:30529165 endosulfan increases expression ISO RGD:1310179 6480464 Endosulfan results in increased expression of ZFP593 mRNA CTD PMID:29391264 ethyl methanesulfonate decreases expression ISO RGD:1320928 6480464 Ethyl Methanesulfonate results in decreased expression of ZNF593 mRNA CTD PMID:23649840 flavonoids increases expression ISO RGD:1320928 6480464 Flavonoids results in increased expression of ZNF593 mRNA CTD PMID:15465739 flutamide increases expression ISO RGD:1310179 6480464 Flutamide results in increased expression of ZFP593 mRNA CTD PMID:24136188 hexane increases methylation ISO RGD:1310179 6480464 n-hexane results in increased methylation of ZFP593 promoter CTD PMID:23740543 menadione affects expression ISO RGD:1320928 6480464 Vitamin K 3 affects the expression of ZNF593 mRNA CTD PMID:20044591 methyl methanesulfonate decreases expression ISO RGD:1320928 6480464 Methyl Methanesulfonate results in decreased expression of ZNF593 mRNA CTD PMID:23649840 nickel atom increases expression ISO RGD:1320928 6480464 Nickel results in increased expression of ZNF593 mRNA CTD PMID:24768652 , PMID:25583101 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ZFP593 mRNA CTD PMID:17562736 phenobarbital affects expression ISO RGD:1320928 6480464 Phenobarbital affects the expression of ZNF593 mRNA CTD PMID:19159669 rotenone decreases expression ISO RGD:1310179 6480464 Rotenone results in decreased expression of ZNF593 mRNA CTD PMID:19013527 sodium dichromate increases expression ISO RGD:1310179 6480464 sodium bichromate results in increased expression of ZFP593 mRNA CTD PMID:25993096 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of ZFP593 mRNA CTD PMID:17555576 tert-butyl hydroperoxide increases expression ISO RGD:1320928 6480464 tert-Butylhydroperoxide results in increased expression of ZNF593 mRNA CTD PMID:15336504 tetrachloromethane increases expression ISO RGD:1310179 6480464 Carbon Tetrachloride results in increased expression of ZFP593 mRNA CTD PMID:31150632 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of ZFP593 mRNA CTD PMID:23557971 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of ZFP593 mRNA CTD PMID:29264374 tungsten increases expression EXP 6480464 Tungsten results in increased expression of ZFP593 mRNA CTD PMID:30912803 urethane decreases expression ISO RGD:1320928 6480464 Urethane results in decreased expression of ZNF593 mRNA CTD PMID:28818685 valdecoxib increases expression ISO RGD:1310179 6480464 valdecoxib results in increased expression of ZFP593 mRNA CTD PMID:24136188 valproic acid decreases methylation ISO RGD:1320928 6480464 Valproic Acid results in decreased methylation of ZNF593 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1320928 6480464 Valproic Acid results in increased expression of ZNF593 mRNA CTD PMID:23179753 vitamin E decreases expression ISO RGD:1320928 6480464 Vitamin E results in decreased expression of ZNF593 mRNA CTD PMID:19244175
Gene Ontology Annotations
Biological Process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO UniProtKB:O00488 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of transcription by RNA polymerase II ISO UniProtKB:O00488 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ribosomal large subunit export from nucleus IBA PANTHER:PTN000466553 , SGD:S000004064 2290270 (PMID:21873635) GO_Central PMID:21873635 Cellular Component nucleolus ISO UniProtKB:O00488 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleoplasm ISO UniProtKB:O00488 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus ISO UniProtKB:O00488 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IEA UniProtKB-KW:KW-0539 2290270 UniProt GO_REF:0000004, MGI:MGI:1354194 preribosome, large subunit precursor IBA PANTHER:PTN000466553 , SGD:S000004064 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function DNA binding IEA UniProtKB-KW:KW-0238 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleic acid binding IEA InterPro:IPR003604 , InterPro:IPR013087 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 ribosomal large subunit binding IBA PANTHER:PTN000466553 , SGD:S000004064 2290270 (PMID:21873635) GO_Central PMID:21873635 zinc ion binding ISO UniProtKB:O00488 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
4142082 Psds2_m psoriasis-like skin disease severity 2 (mouse) Not determined 4 133427367 137890684 Mouse 14746982 Manh56_m mandible shape 56 (mouse) 4 118088606 152088606 Mouse 15039382 Ltgq7_m liver triglyceride QTL 7 (mouse) 4 105812001 139812001 Mouse 15039377 Bw45_m body weight QTL 45 (mouse) 4 105812001 139812001 Mouse 10043985 Stheal12_m soft tissue heal 12 (mouse) Not determined 4 121615338 155615442 Mouse 1301823 Bmd7_m bone mineral density 7 (mouse) Not determined 4 89063832 151570093 Mouse 12910808 Pwbwq9_m post-weaning body weight QTL 9 (mouse) 4 105978113 141706527 Mouse 10047132 Albq19_m albuminuria QTL 19 (mouse) Not determined 4 112930596 146930596 Mouse 4142077 Ignpq2_m IgA nephropathy QTL 2 (mouse) Not determined 4 133592276 156508116 Mouse 4142493 Femwf13_m femur work to failure 13 (mouse) Not determined 116427367 150427471 Mouse 13208562 Wght7_m weight 7 (mouse) 4 91000000 148000000 Mouse 15039378 Adip30_m adiposity 30 (mouse) 4 105812001 139812001 Mouse 1300839 Dyscalc2_m dystrophic cardiac calcinosis 2 (mouse) Not determined 4 111115258 145115487 Mouse 4142061 Chlq16_m circulating hormone level QTL 16 (mouse) Not determined 4 121615338 155615442 Mouse 4141001 Tgq17_m triglyceride QTL 17 (mouse) Not determined 112629696 146629696 Mouse 4142139 Adip12_m adiposity 12 (mouse) Not determined 4 124893970 156508116 Mouse 4141093 W3q17_m weight 3 weeks QTL 17 (mouse) Not determined 89063832 140740892 Mouse 1301584 Lrdg2_m light induced retinal degeneration 2 (mouse) Not determined 4 129572018 151570093 Mouse 1300803 Sluc6_m susceptibility to lung cancer 6 (mouse) Not determined 4 120946694 154946840 Mouse 10412210 Cypr6_m cytokine production 6 (mouse) Not determined 4 120890537 154890684 Mouse 15039385 Mvlq3_m macrovesicular liver lesion QTL 3 (mouse) 4 112288593 146288593 Mouse 1301267 Bcmd2_m B cell maturation defect 2 (mouse) Not determined 4 133427367 150704994 Mouse 1300743 Skull6_m skull morphology 6 (mouse) Not determined 4 111115258 145115487 Mouse 10755531 Lymph3_m lymphocyte differential 3 (mouse) 4 124826172 156508116 Mouse 10755522 Hgb1_m hemoglobin 1 (mouse) 4 108583899 142583899 Mouse 1301793 Tlsr3_m thymic lymphoma suppressor region 3 (mouse) Not determined 4 129572018 137137225 Mouse 1357800 Tgq3_m triglyceride QTL 3 (mouse) Not determined 4 107161300 141161387 Mouse 11533916 Mts1_m mammary tumor susceptibility 1 (mouse) 4 125562755 156508116 Mouse 10755520 Rbc1_m red blood cell count 1 (mouse) 4 108583899 142583899 Mouse 4141549 W10q10_m weight 10 weeks QTL 10 (mouse) Not determined 89063832 140740892 Mouse 4142481 Gct1_m granulosa cell tumorigenesis 1 (mouse) Not determined 4 128057656 156508116 Mouse 1300933 Cdcs9_m cytokine deficiency colitis susceptibility 9 (mouse) Not determined 4 125504302 156508116 Mouse 1357895 Ctrcts_m cataract severity (mouse) Not determined 4 45709925 138615442 Mouse 4141180 Ssic1_m susceptibility to small intestinal cancer 1 (mouse) Not determined 120946694 154946840 Mouse 14696808 Rbcn1_m rod bipolar cell number 1 (mouse) 4 132220000 134320000 Mouse 10045620 Heal22_m wound healing/regeneration 22 (mouse) Not determined 4 125504302 156508116 Mouse 1301982 Pltiq1_m phospholipid transfer protein inducibility QTL 1 (mouse) Not determined 4 124893970 156508116 Mouse 1300621 Tpnr1_m thermal pain response 1 (mouse) Not determined 4 125504302 156508116 Mouse 4141154 Nba1_m New Zealand Black autoimmunity 1 (mouse) Not determined 131923413 141151964 Mouse 1357529 Lvrq8_m liver weight QTL 8 (mouse) Not determined 4 89063832 140740892 Mouse 1300874 Gasa2_m gastritis type A susceptibility locus 2 (mouse) Not determined 4 132926037 156508116 Mouse 13503348 Bntq18_m bone traits QTL 18 (mouse) 4 120890537 154890684 Mouse 4141623 W6q13_m weight 6 weeks QTL 13 (mouse) Not determined 89063832 140740892 Mouse 1301815 Sles2_m systemic lupus erythmatosus suppressor 2 (mouse) Not determined 4 95069342 150592401 Mouse 1300781 Lith8_m lithogenic gene 8 (mouse) Not determined 4 107371164 141371360 Mouse 1302149 Tlsr2_m thymic lymphoma suppressor region 2 (mouse) Not determined 4 124371164 142504390 Mouse 1300858 Tafat_m tally ho associated mesenteric fat pad weight (mouse) Not determined 4 124893970 156508116 Mouse 12910813 Pwbwq4_m pre-weaning body weight QTL 4 (mouse) 4 105978113 141706527 Mouse 1301382 Arvm2_m autoimmune renal vasculitis 2 (mouse) Not determined 4 107897771 141897963 Mouse 1300663 Start2_m startle response 2 (mouse) Not determined 4 107371164 141371360 Mouse 1302102 Bis1_m beta-carboline-induced seizures 1 (mouse) Not determined 4 120137122 154137225 Mouse 11567249 Elorr3_m ethanol induced loss of righting response 3 (mouse) 4 3722677 156183778 Mouse 12910797 Pwgrq4_m pre-weaning growth rate QTL 4 (mouse) 4 105978113 141706527 Mouse 1301525 Lmb1_m lupus in MRL and B6 F2 cross (mouse) Not determined 4 124371164 150592401 Mouse 10755521 Hct1_m hematocrit 1 (mouse) 4 108583899 142583899 Mouse 1300809 Ccrs2_m corpus callosum hemisphere surface size 2 (mouse) Not determined 4 107371164 141371360 Mouse 1302078 Sluc21_m susceptibility to lung cancer 21 (mouse) Not determined 4 117673830 151673964 Mouse 12880433 Fgf23lq1_m FGF23 serum level QTL 1 (mouse) 4 101300000 135300000 Mouse 1301964 Bw8q2_m body weight at 8 weeks QTL 2 (mouse) Not determined 4 120137122 154137225 Mouse 12910794 Pwbwq8_m post-weaning body weight QTL 8 (mouse) 4 105978113 141706527 Mouse 1301452 Elsgp1_m elevated serum gp70 1 (mouse) Not determined 4 121615338 155615442 Mouse 1300917 Gasa1_m gastritis type A susceptibility locus 1 (mouse) Not determined 4 124161300 142711450 Mouse 4141065 Shali2_m survival time to hyperoxic acute lung injury 2 (mouse) Not determined 124161300 141845481 Mouse 10043996 Gct5_m granulosa cell tumorigenesis 5 (mouse) Not determined 4 128057656 156508116 Mouse
Predicted Target Of
Count of predictions: 740 Count of miRNA genes: 425 Interacting mature miRNAs: 511 Transcripts: ENSMUST00000030644, ENSMUST00000129183 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
