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Gene: Hpse2 (heparanase 2) Mus musculus
Symbol: Hpse2
Name: heparanase 2
Description: Predicted to have heparan sulfate proteoglycan binding activity. Involved in extracellular matrix organization and positive regulation of cell population proliferation. Predicted to localize to extracellular matrix. Is expressed in bladder; brain; metanephros; and ureter. Used to study urofacial syndrome. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human HPSE2 (heparanase 2 (inactive)); INTERACTS WITH pioglitazone; 15-acetyldeoxynivalenol (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gm968; heparanase-2; Hpa2; inactive heparanase-2
Homo sapiens (human) : HPSE2 (heparanase 2 (inactive))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hpse2 (heparanase 2 (inactive))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hpse2 (heparanase 2 (inactive))
Pan paniscus (bonobo/pygmy chimpanzee) : HPSE2 (heparanase 2 (inactive))
Canis lupus familiaris (dog) : HPSE2 (heparanase 2 (inactive))
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hpse2 (heparanase 2 (inactive))
Sus scrofa (pig) : HPSE2 (heparanase 2 (inactive))
Chlorocebus sabaeus (African green monkey) : HPSE2 (heparanase 2 (inactive))
Heterocephalus glaber (naked mole-rat) : Hpse2 (heparanase 2 (inactive))
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1942,786,539 - 43,388,355 (-)EnsemblGRCm38mm10GRCm38
GRCm381942,786,541 - 43,388,476 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371942,863,085 - 43,462,801 (-)NCBIGRCm37mm9NCBIm37
MGSCv361942,676,998 - 43,277,483 (-)NCBImm8
MGSCv361942,841,906 - 43,441,622 (-)NCBImm8
Celera1943,584,218 - 44,179,795 (-)NCBICelera
Cytogenetic Map19C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hpse2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1621195
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.