Tpsab1 (tryptase alpha/beta 1) - Chinchilla Research Resource Database
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Gene: Tpsab1 (tryptase alpha/beta 1) Mus musculus
Analyze
Symbol: Tpsab1
Name: tryptase alpha/beta 1
CRRD ID: 1621615
Description: Exhibits peptidase activity. Involved in proteolysis. Localizes to extracellular space and mast cell granule. Is expressed in several structures, including alimentary system; brain; immune system; integumental system; and reproductive system. Orthologous to human TPSAB1 (tryptase alpha/beta 1) and TPSD1 (tryptase delta 1); INTERACTS WITH 4-hydroxyphenyl retinamide; genistein; ozone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mast cell protease 7; mast cell-restricted serine protease 7; Mcp-; Mcp-7; Mcp7; Mcpt; Mcpt7; MGC18524; MMCP-; MMCP-7; tryptase; tryptase alpha/beta-1
Orthologs:
Homo sapiens (human) : TPSAB1 (tryptase alpha/beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tpsab1 (tryptase alpha/beta 1)  Alliance
Sus scrofa (pig) : LOC110255206 (tryptase-like)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,562,219 - 25,564,536 (-)NCBI
GRCm381725,343,245 - 25,345,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,343,245 - 25,345,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,480,364 - 25,482,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv361725,480,190 - 25,482,472 (-)NCBImm8
Celera1725,871,535 - 25,873,843 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1454796   PMID:1688433   PMID:7849408   PMID:8077672   PMID:8576265   PMID:9064323   PMID:9395536   PMID:9398854   PMID:9541598   PMID:10349636   PMID:10783129   PMID:11042159  
PMID:11076861   PMID:11157480   PMID:11217851   PMID:12040188   PMID:12466851   PMID:12477932   PMID:14527958   PMID:14583634   PMID:16141072   PMID:16141073   PMID:16257142   PMID:16730810  
PMID:16774856   PMID:16777228   PMID:18421012   PMID:18668540   PMID:19109198   PMID:21173247   PMID:21873635   PMID:23227233   PMID:23457544   PMID:30571485   PMID:31013764  


Genomics

Comparative Map Data
Tpsab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,562,219 - 25,564,536 (-)NCBI
GRCm381725,343,245 - 25,345,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,343,245 - 25,345,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,480,364 - 25,482,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv361725,480,190 - 25,482,472 (-)NCBImm8
Celera1725,871,535 - 25,873,843 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
TPSAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl161,240,705 - 1,242,554 (+)EnsemblGRCh38hg38GRCh38
GRCh38161,240,705 - 1,242,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37161,290,678 - 1,292,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,230,679 - 1,232,556 (+)NCBINCBI36hg18NCBI36
Celera161,494,229 - 1,494,587 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef161,211,394 - 1,224,921 (-)NCBIHuRef
CHM1_1161,289,978 - 1,291,845 (+)NCBICHM1_1
Tpsab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01014,701,253 - 14,703,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,701,253 - 14,703,668 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,519,181 - 14,521,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,591,590 - 14,594,005 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,591,590 - 14,594,005 (-)NCBI
Celera1014,032,330 - 14,034,745 (-)NCBICelera
Cytogenetic Map10q12NCBI
LOC110255206
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,633,270 - 40,635,783 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Position Markers
L00654  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,343,319 - 25,343,409UniSTSGRCm38
MGSCv371725,480,264 - 25,480,354UniSTSGRCm37
Celera1725,871,609 - 25,871,699UniSTS
Cytogenetic Map17A3.3UniSTS
Whitehead/MRC_RH17314.41UniSTS
M-04423  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,343,253 - 25,343,362UniSTSGRCm38
MGSCv371725,480,198 - 25,480,307UniSTSGRCm37
Celera1725,871,543 - 25,871,652UniSTS
Cytogenetic Map17A3.3UniSTS
Whitehead/MRC_RH17314.62UniSTS
Mcpt7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,343,435 - 25,343,573UniSTSGRCm38
MGSCv371725,480,380 - 25,480,518UniSTSGRCm37
Celera1725,871,725 - 25,871,863UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1710.4UniSTS
Tpsab1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Tpsab1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
Mcpt7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,343,392 - 25,344,857UniSTSGRCm38
MGSCv371725,480,337 - 25,481,802UniSTSGRCm37
Celera1725,871,682 - 25,873,138UniSTS
Cytogenetic Map17A3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125443244Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17125970523Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17125975624Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17126862710Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17126862710Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17392461526182159Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17480447727496965Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171241779526182159Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
12910769Rtmq1_mrenal tumor modifier QTL 1 (mouse)172268105525502498Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:618
Count of miRNA genes:297
Interacting mature miRNAs:327
Transcripts:ENSMUST00000025001, ENSMUST00000146856, ENSMUST00000153118
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000146856   ⟹   ENSMUSP00000157192
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,343,245 - 25,345,562 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153118   ⟹   ENSMUSP00000120741
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,343,245 - 25,345,527 (-)Ensembl
RefSeq Acc Id: NR_033521
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391725,562,219 - 25,564,536 (-)NCBI
GRCm381725,343,245 - 25,345,562 (-)ENTREZGENE
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: ENSMUSP00000157192   ⟸   ENSMUST00000146856
RefSeq Acc Id: ENSMUSP00000120741   ⟸   ENSMUST00000153118
Protein Domains
Peptidase S1

Promoters
RGD ID:13675142
Promoter ID:EPDNEW_M21720
Type:single initiation site
Name:Tpsab1_1
Description:Mus musculus tryptase alpha/beta 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381725,345,562 - 25,345,622EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96943 AgrOrtholog
Ensembl Genes ENSMUSG00000024173 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000120741 UniProtKB/TrEMBL
  ENSMUSP00000157192 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000146856 UniProtKB/TrEMBL
  ENSMUST00000153118 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100503895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96943 ENTREZGENE
NCBI Gene 100503895 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpsab1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.3301 ENTREZGENE
UniProt A0A3Q4L300_MOUSE UniProtKB/TrEMBL
  A1Z090 ENTREZGENE, UniProtKB/TrEMBL
  B5A5B0_MOUSE UniProtKB/TrEMBL
  E9PY32_MOUSE UniProtKB/TrEMBL
  Q02844 ENTREZGENE
  Q921N4_MOUSE UniProtKB/TrEMBL
  TRYB1_MOUSE UniProtKB/Swiss-Prot