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Gene: Irgm1 (immunity-related GTPase family M member 1) Mus musculus
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Symbol: Irgm1
Name: immunity-related GTPase family M member 1
Description: Predicted to have GTPase activity. Involved in several processes, including cellular response to interferon-gamma; positive regulation of autophagy; and positive regulation of interferon-gamma-mediated signaling pathway. Localizes to the autolysosome; late endosome; and phagocytic vesicle. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human IRGM (immunity related GTPase M); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ifggd3; Ifi1; Iigp3; Iipg3; immunity related GTPase m1; immunity-related GTPase family M protein; immunity-related GTPase family M protein 1; immunity-related GTPase family, M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; interferon-inducible GTPase 3; interferon-inducible protein 1; Irgm; LPS-stimulated RAW 264.7 macrophage protein 47; LRG-47
Orthologs:
Homo sapiens (human) : IRGM (immunity related GTPase M)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irgm (immunity-related GTPase M)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irgm (immunity related GTPase M)
Pan paniscus (bonobo/pygmy chimpanzee) : IRGM (immunity related GTPase M)
Canis lupus familiaris (dog) : LOC606863 (immunity-related GTPase family M protein-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irgm (immunity related GTPase M)
Chlorocebus sabaeus (African green monkey) : IRGM (immunity related GTPase M)
Heterocephalus glaber (naked mole-rat) : Irgm (immunity related GTPase M)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1148,861,968 - 48,871,683 (-)EnsemblGRCm38mm10GRCm38
GRCm381148,865,245 - 48,871,420 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371148,678,751 - 48,684,848 (-)NCBIGRCm37mm9NCBIm37
MGSCv361148,708,672 - 48,714,769 (-)NCBImm8
Celera1153,447,611 - 53,453,702 (-)NCBICelera
Cytogenetic Map11B1.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Irgm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1621624
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.