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Gene: Irgm1 (immunity-related GTPase family M member 1) Mus musculus
Symbol: Irgm1
Name: immunity-related GTPase family M member 1
Description: Predicted to have GTPase activity. Involved in several processes, including cellular response to interferon-gamma; positive regulation of autophagy; and positive regulation of interferon-gamma-mediated signaling pathway. Localizes to the autolysosome; late endosome; and phagocytic vesicle. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human IRGM (immunity related GTPase M); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ifggd3; Ifi1; Iigp3; Iipg3; immunity related GTPase m1; immunity-related GTPase family M protein; immunity-related GTPase family M protein 1; immunity-related GTPase family, M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; interferon-inducible GTPase 3; interferon-inducible protein 1; Irgm; LPS-stimulated RAW 264.7 macrophage protein 47; LRG-47
Homo sapiens (human) : IRGM (immunity related GTPase M)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irgm (immunity-related GTPase M)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irgm (immunity related GTPase M)
Pan paniscus (bonobo/pygmy chimpanzee) : IRGM (immunity related GTPase M)
Canis lupus familiaris (dog) : LOC606863 (immunity-related GTPase family M protein-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irgm (immunity related GTPase M)
Chlorocebus sabaeus (African green monkey) : IRGM (immunity related GTPase M)
Heterocephalus glaber (naked mole-rat) : Irgm (immunity related GTPase M)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1148,861,968 - 48,871,683 (-)EnsemblGRCm38mm10GRCm38
GRCm381148,865,245 - 48,871,420 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371148,678,751 - 48,684,848 (-)NCBIGRCm37mm9NCBIm37
MGSCv361148,708,672 - 48,714,769 (-)NCBImm8
Celera1153,447,611 - 53,453,702 (-)NCBICelera
Cytogenetic Map11B1.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Irgm1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1621624
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.