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Gene: Cgas (cyclic GMP-AMP synthase) Mus musculus
Symbol: Cgas
Name: cyclic GMP-AMP synthase
Description: Exhibits chromatin binding activity; cyclic-GMP-AMP synthase activity; and double-stranded DNA binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of cellular response to stress; and regulation of defense response. Localizes to the cytosol and plasma membrane. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human CGAS (cyclic GMP-AMP synthase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2'3'-cGAMP synthase; cGAMP synthase; E330016A19Rik; hypothetical protein LOC214763; m-cGAS; Mab-21 domain containing 1; mab-21 domain-containing protein 1; Mb21d1; uncharacterized protein LOC214763
Homo sapiens (human) : CGAS (cyclic GMP-AMP synthase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cgas (cyclic GMP-AMP synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cgas (cyclic GMP-AMP synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : CGAS (cyclic GMP-AMP synthase)
Canis lupus familiaris (dog) : CGAS (cyclic GMP-AMP synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cgas (cyclic GMP-AMP synthase)
Sus scrofa (pig) : CGAS (cyclic GMP-AMP synthase)
Chlorocebus sabaeus (green monkey) : CGAS (cyclic GMP-AMP synthase)
Heterocephalus glaber (naked mole-rat) : Cgas (cyclic GMP-AMP synthase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl978,430,526 - 78,443,237 (-)Ensembl
GRCm38978,430,518 - 78,443,237 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37978,278,325 - 78,290,954 (-)NCBIGRCm37mm9NCBIm37
MGSCv36978,217,019 - 78,228,921 (-)NCBImm8
Celera975,608,705 - 75,621,492 (-)NCBICelera
Cytogenetic Map9 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Cgas
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1622113
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.