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Gene: Btnl2 (butyrophilin-like 2) Mus musculus
Symbol: Btnl2
Name: butyrophilin-like 2
CRRD ID: 1622608
Description: Exhibits signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation; and positive regulation of interleukin-2 production. Predicted to localize to external side of plasma membrane. Is expressed in intestine and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); berylliosis; coronary artery disease; and sarcoidosis. Orthologous to human BTNL2 (butyrophilin like 2); INTERACTS WITH 4-hydroxyphenyl retinamide; buta-1,3-diene; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BTL; BTL-II; Btl2; BTLN2; butyrophilin-like protein 2; butyrophylin-like MHC class II associated; Gm315; NG; NG9
Homo sapiens (human) : BTNL2 (butyrophilin like 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Btnl2 (butyrophilin-like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btnl2 (butyrophilin like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BTNL2 (butyrophilin like 2)
Canis lupus familiaris (dog) : BTNL2 (butyrophilin like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btnl2 (butyrophilin like 2)
Sus scrofa (pig) : BTNL2 (butyrophilin like 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,573,763 - 34,588,466 (+)NCBI
GRCm381734,354,789 - 34,369,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,354,822 - 34,369,495 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,491,767 - 34,506,437 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,962,403 - 33,977,115 (+)NCBImm8
Celera1737,117,517 - 37,137,992 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Btnl2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1622608
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.