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Gene: Otulin (OTU deubiquitinase with linear linkage specificity) Mus musculus
Symbol: Otulin
Name: OTU deubiquitinase with linear linkage specificity
Description: Exhibits thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Localizes to cytoplasm. Colocalizes with LUBAC complex. Human ortholog(s) of this gene implicated in otulipenia. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity); INTERACTS WITH trimellitic anhydride; 17beta-hydroxy-5alpha-androstan-3-one (ortholog); acrylamide (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C79097; deubiquitinating enzyme otulin; Fam105b; family with sequence similarity 105, member B; gumby; hypothetical protein LOC432940; m3Sapc; m7-1Sapc; OTU domain-containing deubiquitinase with linear linkage specificity; ubiquitin thioesterase Gumby; ubiquitin thioesterase otulin
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1527,542,635 - 27,630,693 (-)EnsemblGRCm38mm10GRCm38
GRCm381527,597,055 - 27,630,977 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371527,535,674 - 27,560,448 (-)NCBIGRCm37mm9NCBIm37
MGSCv361527,550,644 - 27,564,262 (-)NCBImm8
Celera1528,353,849 - 28,378,669 (-)NCBICelera
Cytogenetic Map15B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Otulin
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1623582
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.